{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:17:06Z","timestamp":1792009026660,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Upper gastrointestinal bleeding (UGIB) remains a common cause of presentation and admission to hospital in the UK, with the incidence in Scotland one of the highest in the world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the difference in demographics, deprivation quintiles, aetiology of bleeding and clinical outcomes in patients presenting with UGIB to hospitals across Scotland over a 16\u2010year period<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected using the National Data Catalogue and analysed retrospectively using the National Safe Haven.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 129\u00a0404 patients. The annual number of patients presenting with UGIB remained similar over the 16\u2010year period. Mean age at admission increased from 59.2 to 61.4 years. There was a significant drop in variceal bleeding over time from 2.2% to 1.7% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The incidence of UGIB was highest in the more deprived quintiles. There was a significant decrease in 30\u2010day case\u2010fatality from 10.1% in 2000 to 7.9% in 2015 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), which was observed across all deprivation quintiles. Mean length of stay fell from 3.9 to 2.1\u00a0days. There was no difference in 30\u2010day case\u2010fatality or mean length of stay between patients presenting on weekdays or at weekends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this national study, we demonstrated that case\u2010fatality and mean length of stay after presentation with UGIB in Scotland has fallen over the past 16\u00a0years, despite a rise the in mean age of patients. There is a positive correlation between the incidence of UGIB and deprivation. We found no evidence of worse outcomes among patients presenting at weekends.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16170","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:17:16Z","timestamp":1693765036000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Upper gastrointestinal bleeding in Scotland 2000\u20102015: trends in demographics, aetiology and outcomes"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-4257","authenticated-orcid":false,"given":"Sardar","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Glasgow Royal Infirmary Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-7098","authenticated-orcid":false,"given":"Daniel","family":"Mackay","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8898-7035","authenticated-orcid":false,"given":"Jill P.","family":"Pell","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Morris","sequence":"additional","affiliation":[{"name":"Glasgow Royal Infirmary Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas I.","family":"Church","sequence":"additional","affiliation":[{"name":"Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fraser","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary Aberdeen UK"},{"name":"Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9761-9795","authenticated-orcid":false,"given":"Adrian J.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Glasgow Royal Infirmary Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NICE.Acute upper gastrointestinal bleeding in over 16s: management.2012.https:\/\/www.nice.org.uk\/guidance\/cg141"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.017558"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7107.510"},{"key":"e_1_2_8_5_1","first-page":"436","article-title":"Upper gastrointestinal bleeding in an open\u2010access dedicated unit","volume":"30","author":"Masson J","year":"1996","journal-title":"J R Coll Physicians Lond"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.228437"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393172"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l536"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-1795"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309262"},{"key":"e_1_2_8_11_1","unstructured":"National Confidential Enquiry into Patient Outcome and Death (NCEPOD).Time to get control? 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