{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:09:39Z","timestamp":1787944179036,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abdominal or pelvic radiotherapy in inflammatory bowel disease (IBD) patients raises concerns regarding the risk of worsening of underlying disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the impact of radiotherapy on IBD course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective multicentre study including IBD patients exposed to abdominal or pelvic irradiation was conducted, retrieving IBD activity by semester (6\u2010month periods) before (from S\u20104 to S\u20101) and after (from S\u00a0+\u00a01 to S\u00a0+\u00a06) radiotherapy and IBD flare during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients (32 women, mean age 59\u00a0years), with 467 patient semesters of follow\u2010up, treated for digestive (n\u00a0=\u00a031), urinary tract (n\u00a0=\u00a023) and gynaecological cancers (n\u00a0=\u00a07) were included. Rates of IBD activity per semester were, respectively, 21% (95% CI: 16\u201027) from S\u20104 to S\u20101; 12% (7\u201019) from S\u00a0+\u00a01 to S\u00a0+\u00a03 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.15 vs S\u20104 to S\u20101) and 16% (10\u201025) from S\u00a0+\u00a04 to S\u00a0+\u00a06 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.45 vs S\u20104 to S\u20101). With a median follow\u2010up of 156 weeks (interquartile range: 82\u2010365), rates of survival without IBD flare at 1 and 3\u00a0years after radiotherapy were 82.5% (73.2\u201093.0) and 70.6% (58.8\u201084.7). Moderate\u2010to\u2010severe acute radiotherapy\u2010induced gut toxicity and the absence of concomitant chemotherapy were independently associated with an increased risk of flare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most patients with non\u2010active IBD can be safely treated with abdominal or pelvic radiotherapy. Patients having acute gut toxicity and those without concomitant chemotherapy should be more closely monitored in the post\u2010radiotherapy period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16176","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:17:16Z","timestamp":1693765036000},"page":"400-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of abdominal or pelvic radiotherapy on disease activity in inflammatory bowel disease: a multicentre cohort study from the GETAID"],"prefix":"10.1111","volume":"53","author":[{"given":"Doriane","family":"Broussard","sequence":"first","affiliation":[{"name":"Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-2806","authenticated-orcid":false,"given":"Pauline","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Bordeaux 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