{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:38:56Z","timestamp":1785220736797,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1382 (ID 403224013)"],"award-info":[{"award-number":["SFB 1382 (ID 403224013)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STR 1095\/6\u20101"],"award-info":[{"award-number":["STR 1095\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coeliac disease arises in genetically susceptible individuals, in particular in carriers of HLA\u2010DQ2\/DQ8 risk alleles and is associated with various comorbidities. Coeliac disease may confer an increased mortality, but the data are conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to characterize mortality and morbidity in patients with coeliac disease with a special focus on the role of the number of HLA risk alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied coeliac disease\u2010associated morbidity and mortality in ~500\u00a0000 participants of the UK Biobank including 2482 individuals with the diagnosis of coeliac disease. We used an unbiased, multivariable Phenome\u2010Wide Association Study (PheWAS) method to uncover the coeliac disease\u2010associated disorders. The tag SNP approach was used to divide the coeliac disease subjects into HLA\u2010DQ2\/DQ8\u2010based risk categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 225 ICD\u201010 codes significantly associated with coeliac disease. During the median follow\u2010up of 10.7\u00a0years, coeliac disease individuals (n\u00a0=\u00a02482) had higher overall mortality (HR 1.6 [95% CI, 1.4\u20101.8]) than controls and both an increased occurrence of and an increased mortality from cancer, respiratory and cardiovascular diseases (HR 1.4\u20101.6). Coeliac disease individuals with 2 HLA\u2010DQ2\/8 risk alleles had a similar overall mortality as coeliac disease participants with 0\u20101 HLA\u2010DQ2\/8 alleles, but were more likely to die from lymphoproliferative diseases (HR 7.6 [95% CI, 1.01\u201057.25]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that the increased mortality from lymphoproliferative diseases is restricted to those coeliac patients with 2 HLADQ2\/8 alleles and that a combination of coeliac disease and HLADQ2\/8 alleles is needed to increase the susceptibility. Once confirmed, closer monitoring may be warranted in this high\u2010risk subpopulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16206","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T05:35:30Z","timestamp":1693719330000},"page":"510-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phenome\u2010wide association study in adult coeliac disease: role of HLA subtype"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-9246","authenticated-orcid":false,"given":"Carolin V.","family":"Schneider","sequence":"first","affiliation":[{"name":"The Institute for Translational Medicine and Therapeutics The Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"},{"name":"Medical Clinic III Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen Aachen 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