{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:58:40Z","timestamp":1793336320242,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several prognostic tests for primary sclerosing cholangitis (PSC) have been developed, including biochemical models, elastography and magnetic resonance imaging scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To conduct a systematic review of non\u2010invasive prognostic tests for PSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted from 1987 to 2020 of blood tests, biochemical models, elastography and imaging scores associated with outcomes in PSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty studies of prognostic tests that collectively included 16\u00a0094 subjects with PSC were reviewed, of which 26 studies of non\u2010invasive tests including 13\u00a0759 subjects with PSC were included. Normalisation or reduction of alkaline phosphatase with or without therapy was associated with transplant\u2010free survival and reduced risk of hepatobiliary cancers but cut\u2010off values for alkaline phosphatase were not consistent among studies. The most studied prognostic biochemical model was the Mayo Risk Score (MRS) evaluated in 18 studies with a c\u2010statistic from 0.63 to 0.85 for clinical outcomes. One study demonstrated that the UK\u2010PSC score outperforms MRS for predicting clinical outcomes with a c\u2010statistics of 0.81and 0.75 respectively. A transient elastography score greater than 11.1\u00a0kPa is associated with survival and liver\u2010related complications. The Anali score, derived from specific MRI and MRCP features, is associated with the development of cholangiocarcinoma and decompensated cirrhosis. Promising prognostic models include the enhanced liver fibrosis (ELF) score, ELF test and PREsTo scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MRS is the most studied prognostic score for clinical outcomes in PSC but the UK\u2010PSC score and PREsTo have better test performance. Further studies comparing MRS to UK\u2010PSC score, PREsTo or ELF with elastography or imaging\u2010based scores are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16296","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T06:30:15Z","timestamp":1693549815000},"page":"774-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Systematic review: non\u2010invasive prognostic tests for primary sclerosing cholangitis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-0663","authenticated-orcid":false,"given":"Areej","family":"Mazhar","sequence":"first","affiliation":[{"name":"Division of Hepatology Carolinas Medical Center Atrium Health Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Russo","sequence":"additional","affiliation":[{"name":"Division of Hepatology Carolinas Medical Center Atrium Health Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26565"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30300-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1377"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.12.008"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"246","article-title":"Alkaline phosphatase normalization is a biomarker of improved survival in primary sclerosing cholangitis","volume":"15","author":"Hilscher M","year":"2016","journal-title":"Ann Hepatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12979"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.10.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27825"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30479"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313681"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30085"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13088"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.038"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)64614-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90618-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02366-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000461"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.03.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.12.030"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.10.041"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26620"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3805-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000042"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30847"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13979"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i29.5412"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.272.cho"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44762-7"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001381"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30237"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.023"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.112"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000115"}],"container-title":["Alimentary Pharmacology &amp; 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