{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:32:22Z","timestamp":1788107542558,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastro\u2010oesophageal reflux is considered the main risk factor for Barrett's oesophagus. The role of other potential risk factors for the development of Barrett's oesophagus in patients with gastro\u2010oesophageal reflux symptoms is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To perform a systematic review and meta\u2010analysis examining risk factors in development of Barrett's oesophagus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline, Embase and Embase Classic were searched (until December 2020) to identify cross\u2010sectional studies reporting prevalence of Barrett's oesophagus based on presence of one or more proposed risk factors in individuals with gastro\u2010oesophageal reflux symptoms. Prevalence of Barrett's oesophagus was compared according to presence or absence of each risk factor in individuals with gastro\u2010oesophageal reflux symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 7164 citations evaluated, 13 studies reported prevalence of Barrett's oesophagus in 11\u00a0856 subjects. Pooled prevalence of histologically confirmed Barrett's oesophagus in individuals with gastro\u2010oesophageal reflux symptoms in all studies was 7.0% (95% CI 4.8% to 9.6%). Prevalence was higher in subjects with hiatal hernia (OR 2.74; 95% CI 1.58 to 4.75) and in those who drank alcohol (OR 1.51; 95% CI 1.17 to 1.95). Other features including non\u2010steroidal anti\u2010inflammatory drugs and\/or aspirin use (OR 1.19; 95% CI 1.00 to 1.42), smoking (OR 1.14; 95% CI 0.96 to 1.35) or obesity (OR 1.10; 95% CI 0.92 to 1.33) were not significantly associated with Barrett's oesophagus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of Barrett's oesophagus in individuals with gastro\u2010oesophageal reflux symptoms was higher in those who drank alcohol, although this association was modest. The strongest association found was between hiatal hernia and Barrett's oesophagus. Other potential risk factors assessed in this study did not appear to be associated with presence of Barrett's oesophagus among individuals with gastro\u2010oesophageal symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16321","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T01:09:18Z","timestamp":1648170558000},"page":"968-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Systematic review with meta\u2010analysis: risk factors for Barrett's oesophagus in individuals with gastro\u2010oesophageal reflux symptoms"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-7744","authenticated-orcid":false,"given":"Leonardo H.","family":"Eusebi","sequence":"first","affiliation":[{"name":"Gastroenterology and Endoscopy Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical 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