{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:15:09Z","timestamp":1782206109787,"version":"3.54.5"},"reference-count":168,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coeliac disease is one of the most prevalent immune\u2010mediated gastrointestinal disorders in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review and meta\u2010analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. A total of 127 eligible studies were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of previously undiagnosed coeliac disease from screening surveys (histology based) ranged from 0.10% to 3.03% (median\u00a0=\u00a00.70%), with a significantly increasing annual trend (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029). Prevalence since 2000 was significantly higher in northern Europe (1.60%) than in eastern (0.98%), southern (0.69%) and western (0.60%) Europe. Large increases in the incidence of diagnosed coeliac disease across Europe have reached 50 per 100\u00a0000 person\u2010years in Scandinavia, Finland and Spain. The median age at diagnosis increased from 1.9\u00a0years before 1990 to 7.6 since 2000. Larger increases in incidence were found in older age groups than in infants and ages &lt;5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paediatric coeliac disease incidence and prevalence have risen across Europe and appear highest in Scandinavia, Finland and Spain. The most recent evidence shows large increases in incidence in most regions, but stabilisation in some (notably Sweden and Finland). Sharp increases in the age at diagnosis may reflect increases in milder and asymptomatic cases diagnosed since reliable serology testing became widely used, through endomysial antibodies after 1990 and tissue transglutaminase antibodies around 2000.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16337","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T19:15:13Z","timestamp":1623438913000},"page":"109-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Systematic review and meta\u2010analysis: the incidence and prevalence of paediatric coeliac disease across Europe"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7981-520X","authenticated-orcid":false,"given":"Stephen E.","family":"Roberts","sequence":"first","affiliation":[{"name":"Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Morrison\u2010Rees","sequence":"additional","affiliation":[{"name":"Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-9951","authenticated-orcid":false,"given":"Nikhil","family":"Thapar","sequence":"additional","affiliation":[{"name":"London UK"},{"name":"Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-0508","authenticated-orcid":false,"given":"Osvaldo","family":"Borrelli","sequence":"additional","affiliation":[{"name":"London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-3064","authenticated-orcid":false,"given":"Ilse","family":"Broekaert","sequence":"additional","affiliation":[{"name":"Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-5592","authenticated-orcid":false,"given":"Jernej","family":"Dolinsek","sequence":"additional","affiliation":[{"name":"Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Martin\u2010de\u2010Carpi","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-7352","authenticated-orcid":false,"given":"Emmanuel","family":"Mas","sequence":"additional","affiliation":[{"name":"Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-7305","authenticated-orcid":false,"given":"Erasmo","family":"Miele","sequence":"additional","affiliation":[{"name":"Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-1401","authenticated-orcid":false,"given":"Corina","family":"Pienar","sequence":"additional","affiliation":[{"name":"Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ribes\u2010Koninckx","sequence":"additional","affiliation":[{"name":"Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-0741","authenticated-orcid":false,"given":"Rut A.","family":"Thomassen","sequence":"additional","affiliation":[{"name":"Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Thomson","sequence":"additional","affiliation":[{"name":"Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-1649","authenticated-orcid":false,"given":"Christos","family":"Tzivinikos","sequence":"additional","affiliation":[{"name":"Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kymberley","family":"Thorne","sequence":"additional","affiliation":[{"name":"Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"John","sequence":"additional","affiliation":[{"name":"Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-9055","authenticated-orcid":false,"given":"John G.","family":"Williams","sequence":"additional","affiliation":[{"name":"Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.11.1473"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1970.tb15545.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.10.783"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614554154"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa037"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.11.013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12373"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.523229"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.281.sys"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13270"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000523"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.014"},{"key":"e_1_2_10_19_1","first-page":"14","volume-title":"Common food intolerances: epidemiology of coeliac disease","author":"Greco L","year":"1992"},{"key":"e_1_2_10_20_1","first-page":"485","article-title":"Burden of celiac disease in Europe: a review of its childhood and adulthood prevalence and incidence as of September 2014","volume":"26","author":"Altobelli E","year":"2014","journal-title":"Ann Ig"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1983.tb22220.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0797-797"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1260"},{"key":"e_1_2_10_25_1","unstructured":"QGIS Development Team.QGIS geographic information system. Open source geospatial foundation. http:\/\/qgis.osgeo.org;2009."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000331"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000446"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144346"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.057"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001307"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615571021"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-59"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000992"},{"key":"e_1_2_10_34_1","unstructured":"ListerM WoodP HendersonP GillettP.The rising incidence of childhood coeliac disease: a 7\u2010year regional cohort study. Coeliac UK research Conference; 2018; London UK;2018."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1835-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0845-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307105"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.3.206"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00521.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.55"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.915054"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.5.465"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90929-7"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1979.tb05026.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a455dd"},{"key":"e_1_2_10_47_1","first-page":"621","article-title":"Epidemiology of coeliac disease in children in one Croatian county: the cumulative incidence over ten\u2010year period and the way of clinical presentation (Part I)","volume":"23","author":"Matek Z","year":"1999","journal-title":"Coll Antropol"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200304000-00020"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0932"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303113"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02392.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023107"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199700001-00003"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.5.389"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.505931"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.98"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.029"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199700001-00002"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.02.005"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.2.113"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a455dd"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404172"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198411000-00006"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80074-8"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311232"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70007-1"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.094045"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2373"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181fa434f"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1015"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14468"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.119"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10395"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1551-5"},{"key":"e_1_2_10_75_1","first-page":"325","article-title":"Seroprevalence of celiac disease in Belgian children and adolescents","volume":"75","author":"Vijgen S","year":"2012","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002052"},{"key":"e_1_2_10_77_1","first-page":"553","article-title":"The prevalence of celiac disease in children and adolescents in Germany","volume":"112","author":"Laass MW","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12241"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39405.472975.80"},{"key":"e_1_2_10_80_1","article-title":"Increased prevalence of celiac disease in school\u2010age children in Italy","author":"Gatti S","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31827b7f64"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-67"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181e6f2d0"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.898269"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1354-x"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04543.x"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001007"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.041459"},{"key":"e_1_2_10_89_1","first-page":"595","article-title":"Prevalence of celiac disease among school\u2010age children in Corum, Turkey","volume":"29","author":"Comba A","year":"2018","journal-title":"Turk J Gastroenterol"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.183"},{"key":"e_1_2_10_91_1","first-page":"14","article-title":"Human tissue transglutaminase antibody screening by immunochromatographic line immunoassay for early diagnosis of celiac disease in Turkish children","volume":"19","author":"Demirceken FG","year":"2008","journal-title":"Turk J Gastroenterol"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31812e5710"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.07.012"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021687"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32757"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199901000-00008"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023408"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.029603"},{"key":"e_1_2_10_99_1","first-page":"95","article-title":"Silent celiac disease: results of a study in secondary schools of Padua","volume":"19","author":"Guariso G","year":"1997","journal-title":"Pediatr Med Chir"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010648122797"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90989-X"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13725.x"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74871-6"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14244.x"},{"key":"e_1_2_10_105_1","first-page":"475","article-title":"Screening for celiac disease in children attending secondary school around Lucca","volume":"48","author":"Montesanti M","year":"1996","journal-title":"Minerva Pediatr"},{"key":"e_1_2_10_106_1","first-page":"352","article-title":"Subclinical coeliac disease","volume":"24","author":"Mazzetti di Pietralata MGG","year":"1992","journal-title":"Ital J Gastroenterol"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00243-3"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.43"},{"key":"e_1_2_10_109_1","first-page":"PH7\u201011","article-title":"Screening for celiac disease in Poland","volume":"15","author":"Szaflarska\u2010Poplawska A","year":"2009","journal-title":"Med Sci Monit"},{"key":"e_1_2_10_110_1","first-page":"115","article-title":"First determination of the prevalence of celiac disease in a Portuguese population","volume":"19","author":"Antunes H","year":"2006","journal-title":"Acta Med Port"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701678689"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200407000-00016"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.1.42"},{"key":"e_1_2_10_114_1","first-page":"43","article-title":"Prevalence of asymptomatic celiac disease in adolescents of eastern Switzerland","volume":"132","author":"Rutz R","year":"2002","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000174026.26838.56"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01740.x"},{"key":"e_1_2_10_117_1","first-page":"20","article-title":"An epidemiologic survey of celiac disease in the Terni area (Umbria, Italy) in 2002\u20132010","volume":"53","author":"Angeli G","year":"2012","journal-title":"J Prev Med Hyg"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3103-4"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302056"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1200"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12494"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328350f888"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00443568"},{"key":"e_1_2_10_124_1","first-page":"614","article-title":"Incidence of celiac disease in northern Moravia 1965\u20131989","volume":"48","author":"Kolek A","year":"1993","journal-title":"Cesk Pediatr"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199507000-00011"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90039-4"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12256.x"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl061"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03871.x"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2017-000137"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4663.1157"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1995.tb00079.x"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199401000-00009"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11367.x"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10668.x"},{"key":"e_1_2_10_136_1","first-page":"123","article-title":"The incidence of coeliac disease and pyloric stenosis in children in Northern Finland","volume":"14","author":"Kokkonen J","year":"1982","journal-title":"Ann Clin Res"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91869-9"},{"key":"e_1_2_10_138_1","first-page":"107","article-title":"Incidence of symptomatic celiac disease in French children","volume":"30","author":"Baudon JJ","year":"2001","journal-title":"Presse Med"},{"key":"e_1_2_10_139_1","first-page":"539","article-title":"Epidemiologic profile of celiac disease in Seine\u2010Maritime (1972\u20131981)","volume":"50","author":"Mouterde O","year":"1993","journal-title":"Arch Fr Pediatr"},{"key":"e_1_2_10_140_1","first-page":"325","article-title":"Gluten enteropathy in children from south\u2010eastern France (author's transl)]","volume":"10","author":"Chapoy P","year":"1981","journal-title":"Nouv Presse Med"},{"key":"e_1_2_10_141_1","first-page":"361","article-title":"Editorial: the incidence of celiac disease","volume":"63","author":"Bernier JJ","year":"1974","journal-title":"Arch Fr Mal App Dig"},{"key":"e_1_2_10_142_1","first-page":"716","article-title":"Epidemiologic studies of celiac disease in childhood in the Dresden district","volume":"31","author":"Henker J","year":"1993","journal-title":"Z Gastroenterol"},{"key":"e_1_2_10_143_1","first-page":"327","article-title":"The incidence of endemic sprue\/celiac disease in Berlin (West). A prospective study with short discussion of a case","volume":"29","author":"Sandforth F","year":"1991","journal-title":"Z Gastroenterol"},{"key":"e_1_2_10_144_1","first-page":"662","article-title":"Incidence of endemic sprue in Berlin (West). A retrospective study based on biopsy findings","volume":"25","author":"Gutschmidt S","year":"1987","journal-title":"Z Gastroenterol"},{"key":"e_1_2_10_145_1","first-page":"393","article-title":"A nationwide epidemiological study on celiac disease\u2010the Icelandic picture","volume":"81","author":"Sigmundsson J","year":"1995","journal-title":"Laeknabladid"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5855.703"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02026721"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441511"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.013"},{"key":"e_1_2_10_150_1","first-page":"850","article-title":"Twenty years of childhood coeliac disease in the Netherlands: more diagnoses and a changed clinical picture","volume":"142","author":"George EK","year":"1998","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.1.61"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199502000-00015"},{"key":"e_1_2_10_153_1","first-page":"3503","article-title":"Gastrointestinal endoscopy in children","volume":"120","author":"Perminow G","year":"2000","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_10_154_1","first-page":"1729","article-title":"Incidence of gluten\u2010induced celiac disease in the Katowice province in the years 1957\u20131967","volume":"25","author":"Zareba J","year":"1970","journal-title":"Pol Tyg Lek"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03594.x"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693308202700315"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.6.2.129"},{"key":"e_1_2_10_158_1","first-page":"251","article-title":"[Incidence of celiac disease in Vizcaya]","volume":"35","author":"Vitoria Cormenzana JC","year":"1991","journal-title":"An Esp Pediatr"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.1.36"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12810.x"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12541.x"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12306.x"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198709000-00008"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1981.tb16567.x"},{"key":"e_1_2_10_165_1","article-title":"The incidence of coeliac disease in Sweden","volume":"57","author":"Borgfors N","year":"1968","journal-title":"Acta Paediatr Scand"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-8114-3_4"},{"key":"e_1_2_10_167_1","first-page":"421","article-title":"The incidence of coeliac disease in children in Switzerland","volume":"37","author":"Stirum J","year":"1982","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012030-00013"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.2.198b"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.16337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:33:55Z","timestamp":1693416835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":168,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/apt.16337"],"URL":"https:\/\/doi.org\/10.1111\/apt.16337","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,11]]},"assertion":[{"value":"2020-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}