{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:58:12Z","timestamp":1791853092768,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term outcome of patients after antitumour necrosis factor alpha (anti\u2010TNF) discontinuation is not well known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the risk of relapse in the long\u2010term after anti\u2010TNF discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an extension of the evolution after anti\u2010TNF discontinuation in patients with inflammatory bowel disease (EVODIS) study (Crohn's disease or ulcerative colitis patients treated with anti\u2010TNFs in whom these drugs were withdrawn after achieving clinical remission) based in the same cohort of patients whose outcome was updated. Clinical remission was defined as a Harvey\u2013Bradshaw index \u22644 points in Crohn's disease, a partial Mayo score \u22642 in ulcerative colitis and the absence of fistula drainage despite gentle finger compression in perianal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This was an observational, retrospective, multicenter study. A total of 1055 patients were included. The median follow\u2010up time was 34\u00a0months. The incidence rate of relapse was 12% per patient\u2010year (95% confidence interval [CI]\u00a0=\u00a011\u201014). The cumulative incidence of relapse was 50% (95% CI\u00a0=\u00a047\u201053): 19% at one year, 31% at 2\u00a0years, 38% at 3\u00a0years, 44% at 4\u00a0years and 48% at 5\u00a0years of follow\u2010up. Of the 60% patients retreated with the same anti\u2010TNF after relapse, 73% regained remission. Of the 75 patients who did not respond, 48% achieved remission with other therapies. Of the 190 patients who started other therapies after relapse, 62% achieved remission with the new treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A significant proportion of patients who discontinued the anti\u2010TNF remained in remission. In case of relapse, retreatment with the same anti\u2010TNF was usually effective. Approximately half of the patients who did not respond after retreatment achieved remission with other therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16361","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T14:35:02Z","timestamp":1621866902000},"page":"1277-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical outcome after anti\u2010tumour necrosis factor therapy discontinuation in 1000 patients with inflammatory bowel disease: the EVODIS long\u2010term study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-9638","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Casanova","sequence":"first","affiliation":[{"name":"Madrid 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