{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:10:24Z","timestamp":1774408224194,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data about thiopurines or anti\u2010TNF use during pregnancy in women with inflammatory bowel diseases (IBD) are reassuring. However, many studies are based upon small sample sizes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess IBD medication safety during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the French national health database, which covers more than 99% of the French population, around 65\u00a0000\u00a0000 people, we identified pregnancies ending with a birth in IBD patients in France between 2010 and 2018. Pregnancy outcomes (vital status at birth, birth term, and weight for gestational age) were compared according to treatment exposure during pregnancy using propensity score\u2010weighted marginal logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>27\u00a0729 pregnancies were included: 3554 were exposed to thiopurines monotherapy, 3525 to anti\u2010TNF monotherapy, 839 to combination therapy, and 19\u00a0811 unexposed. Pregnancies exposed to thiopurines monotherapy compared to unexposed pregnancies more frequently resulted in stillbirths (1.0% vs 0.5%, aOR 2.04; 95%CI: 1.18\u20103.55), preterm birth (12.3% vs 7.1%, aOR 1.76; 95%CI: 1.55\u20102.00), large for gestational age (10.6% vs 8.4%, aOR 1.32; 95%CI: 1.13\u20101.53) and less frequently in small for gestational age (9.6% vs 11.1%, aOR 0.79; 95%CI: 0.67\u20100.92). By contrast, pregnancies exposed to anti\u2010TNF monotherapy were not different from unexposed pregnancies as regards to these outcomes. Compared to unexposed pregnancies, those exposed to combination therapy more frequently resulted in preterm births (aOR 1.55; 95%CI: 1.15\u20102.11) and larger for gestational age (aOR 1.61; 95%CI: 1.13\u20102.29) but did not differ as regards to stillbirths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregnancies exposed to thiopurines more frequently resulted in stillbirths, preterm births and large for gestational age compared to pregnancies exposed to anti\u2010TNF or unexposed pregnancies. By contrast, pregnancies exposed to anti\u2010TNF monotherapy were not associated with these outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16448","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T17:36:03Z","timestamp":1624469763000},"page":"302-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparative study of pregnancy outcomes in women with inflammatory bowel disease treated with thiopurines and\/or anti\u2010TNF: a French nationwide study 2010\u20132018"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-9289","authenticated-orcid":false,"given":"Antoine","family":"Meyer","sequence":"first","affiliation":[{"name":"EPIPHARE \u00c9pid\u00e9miologie des produits de sant\u00e9 ANSM\u2010CNAM Denis France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Bic\u00eatre Le Kremlin Bic\u00eatre France"},{"name":"Universit\u00e9 Paris\u2010Saclay Le Kremlin Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-7041","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Drouin","sequence":"additional","affiliation":[{"name":"EPIPHARE \u00c9pid\u00e9miologie des produits de sant\u00e9 ANSM\u2010CNAM Denis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8687-9092","authenticated-orcid":false,"given":"Alain","family":"Weill","sequence":"additional","affiliation":[{"name":"EPIPHARE \u00c9pid\u00e9miologie des produits de sant\u00e9 ANSM\u2010CNAM Denis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-5168","authenticated-orcid":false,"given":"Franck","family":"Carbonnel","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Bic\u00eatre Le 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