{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:22:31Z","timestamp":1790342551788,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Barrett's endoscopic therapy (BET) is well established for neoplasia in Barrett's oesophagus using a concept of complete eradication of all Barrett's. However, long\u2010term efficacy is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To perform a systematic review and meta\u2010analysis to examine long\u2010term efficacy of BET for Barrett's neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases were searched for studies meeting stringent criteria: (a) subjects with high\u2010grade dysplasia and\/or superficial adenocarcinoma who underwent BET (ablation\u00a0\u00b1\u00a0endoscopic mucosal resection); (b) BET completion by confirmation of complete eradication of neoplasia (CE\u2010N) and intestinal metaplasia (CE\u2010IM) with systematic sampling and (c) clearly defined follow\u2010up (endoscopy and biopsy) protocol of \u22652\u00a0years thereafter for detection of recurrence. Pooled estimates of CE\u2010N and CE\u2010IM after BET completion and follow\u2010up were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies met the stringent criteria (n\u00a0=\u00a0794, males 89%, age 64.6\u00a0years). Despite high efficacy of BET at therapy completion (CE\u2010N: 95.9 [91.7\u201098.7]%; CE\u2010IM: 90.9 [83\u201096.6]%), this declined (CE\u2010N: 89 [73.4\u201098.2]%; CE\u2010IM: 77.8 [65.6\u201088]%) over 3.4\u00a0years of follow\u2010up. There was considerable heterogeneity. Only two studies reported a post\u2010BET follow\u2010up of &gt;5\u00a0years (CE\u2010IM 50 [41.5%\u201058.5]%). Higher person years of follow\u2010up seem to correlate with decrease in BET efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using stringent criteria for appropriate study selection with sufficient follow\u2010up, a lack of high\u2010quality controlled intervention trials becomes evident for assessment of long\u2010term durable remission rates of BET despite initial high success rates. We plea for a uniform documentation of study details which could be used in future trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16473","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T11:20:34Z","timestamp":1624533634000},"page":"222-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Systematic review with meta\u2010analysis: the long\u2010term efficacy of Barrett's endoscopic therapy\u2014stringent selection criteria and a proposal for definitions"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-3627","authenticated-orcid":false,"given":"Madhav","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kansas City VA Medical Center Kansas City MO USA"},{"name":"Department of Gastroenterology and Hepatology University of Kansas School of Medicine Kansas City KS 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