{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:55:33Z","timestamp":1790776533603,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tegoprazan is a novel, fast\u2010 and long\u2010acting potassium\u2010competitive acid blocker that suppresses gastric acid secretion, which could benefit patients with non\u2010erosive reflux disease (NERD), a type of gastroesophageal reflux disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety profiles of tegoprazan compared with those of a placebo in Korean patients with NERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase 3, double\u2010blind, placebo\u2010controlled, multicentre study, 324 Korean patients with NERD were randomised into three treatment groups: tegoprazan 50\u00a0mg, tegoprazan 100\u00a0mg and placebo. These drugs were provided once daily for 4\u00a0weeks. The primary endpoint was the proportion of patients with complete resolution of major symptoms (both heartburn and regurgitation) for the last 7\u00a0days of the 4\u2010week treatment period. Other outcomes related to efficacy, safety and tolerability were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all, 42.5% (45\/106), 48.5% (48\/99) and 24.2% (24\/99) of patients showed complete resolution of major symptoms at week 4 after receiving tegoprazan 50\u00a0mg, tegoprazan 100\u00a0mg, and placebo, respectively. Both doses of tegoprazan showed superior efficacy than the placebo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0058 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0004, respectively). The complete resolution rates of heartburn and proportions of heartburn\u2010free days (as other efficacy outcomes) were significantly higher in both tegoprazan groups than in the placebo group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all). No significant difference in the incidence of treatment\u2010emergent adverse events were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tegoprazan 50 and 100\u00a0mg showed superior therapeutic efficacy compared with the placebo, as well as a favourable safety profile in patients with NERD.<\/jats:p><jats:p><jats:bold>Registration number:<\/jats:bold> ClinicalTrials.gov identifier NCT02556021.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16477","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T11:31:09Z","timestamp":1625571069000},"page":"402-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Randomised clinical trial: comparison of tegoprazan and placebo in non\u2010erosive reflux disease"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-9175","authenticated-orcid":false,"given":"Seung Han","family":"Kim","sequence":"first","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Bum","family":"Cho","sequence":"additional","affiliation":[{"name":"Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-361X","authenticated-orcid":false,"given":"Hoon Jai","family":"Chun","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Ansan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Goo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-9028","authenticated-orcid":false,"given":"Sang Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-5859","authenticated-orcid":false,"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Seong","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojin","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suck Chei","family":"Choi","sequence":"additional","affiliation":[{"name":"Iksan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam Ryong","family":"Jee","sequence":"additional","affiliation":[{"name":"Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Kwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seun Ja","family":"Park","sequence":"additional","affiliation":[{"name":"Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-8740","authenticated-orcid":false,"given":"Soo Heon","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Rong","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun Seog","family":"Song","sequence":"additional","affiliation":[{"name":"Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06750.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30408-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01423.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03511.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04021.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02608.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151249"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05249.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03350.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225631.07039.6d"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18139"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0326-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.08.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.244202"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15438"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16121"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-31"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03451.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01771.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2214-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04508.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00198.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011211"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.146"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000101"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2016.12.001"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01544.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.947"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0492-17"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15185"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15865"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.16477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T21:52:59Z","timestamp":1693000379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/apt.16477"],"URL":"https:\/\/doi.org\/10.1111\/apt.16477","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"2021-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}