{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:43Z","timestamp":1787013883236,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Given the success of direct\u2010acting antivirals (DAAs) in treating hepatitis C (HCV), interest is growing in utilizing solid organs from allografts with active HCV to expand donor availability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To review post\u2010transplant outcomes and patient survival in HCV\u2010negative recipients receiving solid organ transplants (SOT) from viraemic, that is, HCV+\/NAT+ (nucleic acid testing) allografts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted on PubMed and EMBASE from 01\/01\/2007 to 4\/17\/2021 for articles matching eligibility criteria. Two authors independently screened titles and abstracts. Disagreements were solved by a third independent reviewer. Methodological quality assessment was done using a modified Newcastle\u2010Ottawa scale (NOS). Data synthesis was done qualitatively using median, ranges and percentages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010five studies were included (or 852 SOTs): 343 kidney, 233 heart, 204 liver, and 72 lung transplants from viraemic allografts. Of the recipients eligible for sustained virological response at 12\u00a0weeks (SVR12) calculation, 100% achieved cure from HCV. No deaths\/graft failures were reported to be related to HCV transmission. Seven SOT recipients had viral relapse, with all seven patients treated successfully. Four patients developed fibrosing cholestatic hepatitis with complete resolution post\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transplanting viraemic organs into uninfected individuals can become the standard of care for patients who do not have contraindications to DAAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16508","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T16:44:21Z","timestamp":1626367461000},"page":"571-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Systematic review: hepatitis C viraemic allografts to hepatitis C\u2010negative recipients in solid organ transplantation"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-7547","authenticated-orcid":false,"given":"Taaj","family":"Raasikh","sequence":"first","affiliation":[{"name":"Department of Medicine Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taher","family":"Jamali","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avegail","family":"Flores","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology Michael E. DeBakey VA Medical Center Houston TX USA"},{"name":"Section of Gastroenterology Department of Medicine Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald T.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation Department of Surgery Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkat","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Solid\u2010Organ Transplantation Michael E. 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