{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:11:44Z","timestamp":1789582304870,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["DK117058"],"award-info":[{"award-number":["DK117058"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA241164"],"award-info":[{"award-number":["R01 CA241164"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neoplasia detection rate, the proportion of Barrett's oesophagus patients with high\u2010grade dysplasia or oesophageal adenocarcinoma detected at index surveillance endoscopy has been proposed as a quality metric. However, the correlation between neoplasia detection rate and a clinically relevant outcome like post\u2010endoscopy Barrett's neoplasia remains unknown. Post\u2010endoscopy Barrett's neoplasia refers to the rate of high\u2010grade dysplasia or oesophageal adenocarcinoma on repeat endoscopy within one year of an index screening examination revealing non\u2010dysplastic Barrett's oesophagus or low\u2010grade dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess correlation between neoplasia detection rate and post\u2010endoscopy Barrett's neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic search of multiple databases from date of inception to June 2021 to identify cohort studies reporting both neoplasia detection rate and post\u2010endoscopy Barrett's neoplasia. Data from each study were pooled using a random effects model, and their correlation assessed using meta\u2010regression. Heterogeneity was assessed and a priori planned subgroup analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies with 27\u00a0894 patients with Barrett's oesophagus were included. The pooled neoplasia detection rate and post\u2010endoscopy Barrett's neoplasia were 5.0% (95% CI: 3.4%\u20107.1%, I<jats:sup>2<\/jats:sup>\u00a0=\u00a097%) and 19.6% (95% CI: 10.1%\u201034.7%, I<jats:sup>2<\/jats:sup>\u00a0=\u00a096%), respectively. Meta\u2010regression revealed a statistically significant inverse relationship between the two variables (coefficient \u22123.50, 95% CI: \u22124.63 to \u22122.37, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). With every 1% increase of neoplasia detection rate, post\u2010endoscopy Barrett's neoplasia decreased by 3.50%. Heterogeneity was high despite adjusting for study quality and performing several subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a statistically significant inverse correlation between neoplasia detection rate and post\u2010endoscopy Barrett's neoplasia. Additional studies are needed to further validate this correlation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16531","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T18:08:30Z","timestamp":1626631710000},"page":"546-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Systematic review with meta\u2010analysis: neoplasia detection rate and post\u2010endoscopy Barrett's neoplasia in Barrett's oesophagus"],"prefix":"10.1111","volume":"54","author":[{"given":"Nour","family":"Hamade","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit K.","family":"Kamboj","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Krishnamoorthi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Virginia Mason Medical Centre Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-7269","authenticated-orcid":false,"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of California San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie C.","family":"Hassett","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-2317","authenticated-orcid":false,"given":"David A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Kahi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-1441","authenticated-orcid":false,"given":"Hala","family":"Fatima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-1420","authenticated-orcid":false,"given":"Prasad G.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27834"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0898-3523"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.051"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.322"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.04.470"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.01.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1344952"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5067-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.12.027"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.02.022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.156"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.07.058"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000316"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317800"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.07.034"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.089"},{"key":"e_1_2_8_21_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. 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