{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:24:41Z","timestamp":1791991481820,"version":"4.4.0"},"reference-count":131,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["32729160"],"award-info":[{"award-number":["32729160"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["40001034"],"award-info":[{"award-number":["40001034"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ileal and colonic Crohn's disease seem to be two separate entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the main physiological distinctions between the small and the large intestine and to analyse the differences between ileal and colonic Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The relevant literature was critically examined and synthesised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The small and large intestine have fundamental distinctions (anatomy, cellular populations, immune defence, microbiota). The differences between ileal and colonic Crohn's disease are highlighted by a heterogeneous body of evidence including clinical features (natural history of the disease, efficacy of treatments, and monitoring), epidemiological data (smoking status, age, gender) and biological data (genetics, microbiota, immunity, mesenteric fat). However, the contribution of these factors to disease location remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The classification of ileal and colonic Crohn's disease as distinct subphenotypes is well supported by the literature. Understanding of these differences could be exploited to develop more individualised patient care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16536","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T12:56:53Z","timestamp":1627045013000},"page":"779-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Review article: distinctions between ileal and colonic Crohn's disease: from physiology to pathology"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-0434","authenticated-orcid":false,"given":"Nicolas","family":"Pierre","sequence":"first","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Sal\u00e9e","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Vieujean","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Hepato\u2010Gastroenterology and Digestive Oncology Department Li\u00e8ge University Hospital Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Bequet","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Li\u00e8ge University Hospital Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela\u2010Maria","family":"Merli","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Siegmund","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Infectiology and Rheumatology Medical Department Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2011Alice","family":"Meuwis","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Hepato\u2010Gastroenterology and Digestive Oncology Department Li\u00e8ge University Hospital Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology GIGA\u2010Institute University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Hepato\u2010Gastroenterology and Digestive Oncology Department Li\u00e8ge University Hospital Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00465-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.63"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30340-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00424-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.040"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.777"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32415"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002523"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004496"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.034"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.161"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai7795"},{"key":"e_1_2_9_14_1","first-page":"255","article-title":"Histopathology of Crohn's disease and ulcerative colitis","volume":"18","author":"Geboes K","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i41.15216"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3228"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3552"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2011.00767.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80080-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118792"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.77"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900710"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307916"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002701"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.061"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1504"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102222"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00961"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2000.00790.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.067"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.051"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.04.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.10.017"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00254"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12027"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0016-5"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00475.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-842X(96)10057-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.06.002"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322260"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1206095"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.20"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07416"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.048"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3233"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.021"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12599"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00367"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.10.009"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.009"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.049"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312673"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312135"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20783"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2007.52"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.061"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44632"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.06.043"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2008.05.009"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz130"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy331"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00462"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy146"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.009"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301424"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12540"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.24"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20312"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1008035"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12068"},{"key":"e_1_2_9_75_1","volume-title":"Anatomy, Abdomen and Pelvis, Small Intestine","author":"Collins JT","year":"2021"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.898326"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.11.009"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.63"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601810"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344195"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03835.x"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.560680"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2014.43672"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20933"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.09.008"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01870.x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043406"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2016-100686"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.96"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21905"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.298"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301668"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz195"},{"key":"e_1_2_9_94_1","first-page":"425","article-title":"Characterisation of mucosal healing with adalimumab treatment in patients with moderately to severely active Crohn's disease: results from the EXTEND trial","volume":"11","author":"Reinisch W","year":"2017","journal-title":"J Crohns Colitis"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.038"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.037"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710093371502"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.041"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.030"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08512-4"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300777"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00661-9"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505256102"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032805"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104911"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043307"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21213"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.142588"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304190"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130753"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601583"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8780559"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8133-2"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00464-X"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2161"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v6.i4.159"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i23.3668"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.7.990"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120453"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5224-5231.1998"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70362-3"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.009"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1721"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34225"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.9.1071"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.009"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.05.010"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317878"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1601"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04038.x"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00646"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.16536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:58:54Z","timestamp":1693357134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":131,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/apt.16536"],"URL":"https:\/\/doi.org\/10.1111\/apt.16536","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]},"assertion":[{"value":"2021-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}