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Full length articles were selected for review, and secondary and tertiary bibliographies were developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The B cell activating factor is crucial for the maturation and survival of B cells, and it can co\u2010stimulate T cell activation, proliferation, and survival. It can also modulate the immune response by inducing interleukin 10 production by regulatory B cells. A proliferation\u2010inducing ligand modulates and diversifies the antibody response by inducing class\u2010switch recombination in B cells. It can also increase the proliferation, survival, and antigen activation of T cells. These immune stimulatory actions can be modulated by inducing proliferation of regulatory T cells. The B cell activation system has been implicated in diverse autoimmune diseases, and therapeutic blockade is a management strategy now being evaluated in autoimmune hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The B cell activation system has profound effects on B and T cell function in autoimmune diseases. Blockade therapy is being actively evaluated in autoimmune hepatitis. Clarification of the critical pathogenic components of the B cell activation system will improve the targeting, efficacy, and safety of blockade therapy in this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16574","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T19:27:14Z","timestamp":1631302034000},"page":"902-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Review article: targeting the B cell activation system in autoimmune hepatitis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-3065","authenticated-orcid":false,"given":"Albert J.","family":"Czaja","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine and Science Rochester MN 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