{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:34:42Z","timestamp":1792881282904,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conflicting results exist on the association between <jats:italic>Helicobacter pylori<\/jats:italic> infection and gastro\u2010oesophageal reflux (GOR), and its complications, such as erosive oesophagitis (EO) and Barrett's oesophagus (BO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore the association of <jats:italic>H. pylori<\/jats:italic> infection with GOR symptoms and their complications<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Embase, PubMed, Web of Science and Scopus databases through December 2020 for relevant articles. Regarding the association between <jats:italic>H. pylori<\/jats:italic> and GOR symptoms (heartburn, regurgitation or reflux), we included observational studies comparing the prevalence of GOR symptoms between <jats:italic>H. pylori<\/jats:italic>\u2010positive and \u2010negative individuals. Concerning the association between <jats:italic>H. pylori<\/jats:italic> and complications of GOR, we included studies comparing the prevalence of EO or BO between <jats:italic>H. pylori<\/jats:italic>\u2010positive and \u2010negative individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 36 papers were eligible. Based on seven cross\u2010sectional surveys, <jats:italic>H. pylori<\/jats:italic> infection was associated with a lower odds of GOR symptoms (odds ratio [OR] 0.74, 95% confidence interval [CI] 0.61\u20100.90). However, in four case\u2010control studies, <jats:italic>H. pylori<\/jats:italic> infection was not associated with odds of GOR symptoms (OR 1.10, 95% CI 0.85\u20100.1.43). In 26 cross\u2010sectional studies in patients with GOR symptoms, the OR for EO was 0.70 (95% CI 0.58\u20100.84) in <jats:italic>H. pylori<\/jats:italic>\u2010positive vs \u2010negative cases. Based on nine cross\u2010sectional studies in subjects with GOR complications, no significant association was found between <jats:italic>H. pylori<\/jats:italic> infection and either endoscopically\u2010diagnosed (OR 1.84, 95% CI 0.67\u20105.02) or histologically confirmed (OR 0.85, 95% CI 0.60\u20101.20) BO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infection appears to be associated with a decreased odds of GOR symptoms and EO. In contrast, <jats:italic>H. pylori<\/jats:italic> infection did not seem to affect the odds of BO in patients with GER complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16585","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T19:50:07Z","timestamp":1630007407000},"page":"988-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Systematic review with meta\u2010analysis: association of <i>Helicobacter pylori<\/i> infection with gastro\u2010oesophageal reflux and its complications"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-3873","authenticated-orcid":false,"given":"Mohammad","family":"Zamani","sequence":"first","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences Babol Iran"},{"name":"Digestive Diseases Research Center Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Alizadeh\u2010Tabari","sequence":"additional","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Hasanpour","sequence":"additional","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo H.","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4359","authenticated-orcid":false,"given":"Alexander C.","family":"Ford","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research at St. James's University of Leeds Leeds UK"},{"name":"Leeds Gastroenterology Institute Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313589"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.226450"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225631.07039.6d"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321365"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.206"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07199.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336668"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.443"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14561"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069891"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1282-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025840"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.521888"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.37"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00931.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12504"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2010.01092.x"},{"key":"e_1_2_8_23_1","unstructured":"WellsG SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. 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