{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:08:28Z","timestamp":1793318908408,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 receptor agonists may be a treatment option in patients with non\u2010alcoholic fatty liver disease (NAFLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the effects of semaglutide on liver stiffness and liver fat in subjects with NAFLD using non\u2010invasive magnetic resonance imaging (MRI) methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomised, double\u2010blind, placebo\u2010controlled trial enrolled subjects with liver stiffness 2.50\u20104.63\u00a0kPa by magnetic resonance elastography (MRE) and liver steatosis \u226510% by MRI proton density fat fraction (MRI\u2010PDFF). The primary endpoint was change from baseline to week 48 in liver stiffness assessed by MRE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven subjects were randomised to once\u2010daily subcutaneous semaglutide 0.4\u00a0mg (n\u00a0=\u00a034) or placebo (n\u00a0=\u00a033). Change from baseline in liver stiffness was not significantly different between semaglutide and placebo at week 48 (estimated treatment ratio 0.96 (95% CI 0.89, 1.03; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.2798); significant differences in liver stiffness were not observed at weeks 24 or 72. Reductions in liver steatosis were significantly greater with semaglutide (estimated treatment ratios: 0.70 [0.59, 0.84], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002; 0.47 [0.36, 0.60], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001; and 0.50 [0.39, 0.66], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and more subjects achieved a\u00a0\u2265\u00a030% reduction in liver fat content with semaglutide at weeks 24, 48 and 72, (all <jats:italic>P<\/jats:italic> &lt; 0.001). Decreases in liver enzymes, body weight and HbA<jats:sub>1c<\/jats:sub> were also observed with semaglutide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The change in liver stiffness in subjects with NAFLD was not significantly different between semaglutide and placebo. However, semaglutide significantly reduced liver steatosis compared with placebo which, together with improvements in liver enzymes and metabolic parameters, suggests a positive impact on disease activity and metabolic profile.<\/jats:p><jats:p><jats:bold>ClinicalTrials.gov identifier:<\/jats:bold> NCT03357380.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16608","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T01:36:22Z","timestamp":1632792982000},"page":"1150-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":222,"title":["Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non\u2010alcoholic fatty liver disease assessed by magnetic resonance 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