{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:17:08Z","timestamp":1779365828351,"version":"3.53.0"},"reference-count":31,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between autoimmune diseases and microscopic colitis remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the association between autoimmune diseases and microscopic colitis by using a matched case\u2013control design based on nationwide registry data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All adult Danish patients with a diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries. Odds of autoimmune diseases were compared between cases with microscopic colitis and sex\u2010 and age\u2010matched controls from the background population in a 1:10 ratio and evaluated by logistic regression calculating odds ratios (OR) with 95% confidence intervals (CI) adjusted for comorbidity. Analyses were stratified according to sex, age and the subtypes of lymphocytic and collagenous colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 15\u00a0597 cases with microscopic colitis and matched to 155\u00a0910 controls. In total, 3491 (22%) of patients with microscopic colitis had concomitant autoimmune disease compared to 16\u00a0521 (11%) of controls (OR, 2.46; 95% CI, 2.36\u20102.56). Adjusting for comorbidities reduced the OR to 2.09 (95% CI, 2.01\u20102.19). Analyses showed increased ORs with 16 different autoimmune diseases, particularly of gastrointestinal and endocrine origin, and connective tissue disorders. The highest ORs were for coeliac disease (OR\u00a0=\u00a010.15; 95% CI, 8.20\u201012.6), Crohn\u2019s disease (OR\u00a0=\u00a02.47; 95% CI, 2.10\u20102.91) and ulcerative colitis (OR\u00a0=\u00a06.73; 95% CI, 6.20\u20107.30). In stratified analyses younger age at diagnosis and collagenous colitis were associated with higher odds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using nationwide registry data, microscopic colitis was associated with a wide range of autoimmune diseases, especially of gastrointestinal origin. The results suggest an autoimmune predisposition to microscopic colitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16614","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T04:04:11Z","timestamp":1634529851000},"page":"1454-1462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Autoimmune diseases in microscopic colitis: A Danish nationwide case\u2013control study"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-1782","authenticated-orcid":false,"given":"Signe","family":"Wildt","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Medical Department Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-8260","authenticated-orcid":false,"given":"Lars Kristian","family":"Munck","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Medical Department Zealand University Hospital K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Winther\u2010Jensen","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research and Prevention Frederiksberg and Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Jess","sequence":"additional","affiliation":[{"name":"Center for Molecular Prediction of Inflammatory Bowel Disease Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-0356","authenticated-orcid":false,"given":"Nynne","family":"Nyboe 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