{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:08:17Z","timestamp":1785575297898,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphocytic gastritis (LyG) is a histopathologic finding of unknown clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore the clinical epidemiology of LyG and its associations with <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>) infection, coeliac disease (CD) and microscopic colitis (MC)<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, the demographic, clinical, and histopathologic data of patients with and without LyG were compared. Between 2008 and 2020, 1.5 million patients with endoscopic biopsies of the gastroduodenal mucosa were extracted from a database. LyG diagnoses were reviewed to collect detailed information regarding its topographic distribution within the stomach. In a large subgroup of 400\u00a0000 patients, tissue samples from the colon were also available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1\u00a0481\u00a0336 patients, 341 had LyG with <jats:italic>Hp<\/jats:italic> and 2697 had <jats:italic>Hp<\/jats:italic>\u2010negative LyG (with an overall prevalence of 0.21%). In patients with <jats:italic>Hp<\/jats:italic>\u2010negative LyG, 450 (17%) had corpus\u2010predominant LyG, 1068 antrum\u2010predominant LyG (40%), and 1179 pangastric LyG (44%). LyG was more common in males and in subjects aged 50\u201070\u00a0years. There was no significant ethnic variation. Anaemia, diarrhoea, and weight loss were more common in patients with than without LyG. In 35% and 19% of patients, LyG was associated with CD and MC, respectively. All 72 patients with <jats:italic>Hp<\/jats:italic>\u2010positive LyG and 280 of 310 patients with <jats:italic>Hp\u2010<\/jats:italic>negative LyG with follow\u2010up biopsies became free of LyG within a year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most cases of LyG may represent a self\u2010limited expression, frequently associated with other GI conditions, such as <jats:italic>Hp<\/jats:italic> infection, CD, and MC. In most patients, LyG is likely to resolve within a year after its initial diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16621","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T03:46:08Z","timestamp":1632973568000},"page":"1170-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lymphocytic gastritis and its relationships with other gastrointestinal disorders"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-7023","authenticated-orcid":false,"given":"Robert M.","family":"Genta","sequence":"first","affiliation":[{"name":"Inform Diagnostics Irving TX USA"},{"name":"Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Singhal","sequence":"additional","affiliation":[{"name":"Inform Diagnostics Irving TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin O.","family":"Turner","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-7042","authenticated-orcid":false,"given":"Amnon","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Oregon Health &amp; 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