{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:00:40Z","timestamp":1773496840425,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110\u20102314\u2010B\u2010002\u2010172"],"award-info":[{"award-number":["110\u20102314\u2010B\u2010002\u2010172"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["100\u2010P07"],"award-info":[{"award-number":["100\u2010P07"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data are limited regarding the risk of hepatitis C virus (HCV) reinfection after treatment\u2010induced sustained virologic response (SVR) in patients on haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the risk of HCV reinfection among patients on haemodialysis with treatment\u2010induced SVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients on haemodialysis patients who achieved SVR<jats:sub>12<\/jats:sub> with interferon (IFN) or direct\u2010acting antiviral (DAA)\u2010based treatment received follow\u2010up at SVR<jats:sub>24<\/jats:sub> and then biannually with HCV RNA measurements. HCV reinfection was defined as the resurgence of viremia by different viral strains beyond SVR<jats:sub>12<\/jats:sub>. The low\u2010risk general population who achieved SVR<jats:sub>12<\/jats:sub> and who underwent the same post\u2010SVR<jats:sub>12<\/jats:sub> surveillance served as the reference group. Crude reinfection rates per 100 person\u2010years (PYs) were calculated. Multivariate Cox regression analysis was performed to estimate the relative risk of HCV reinfection between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We recruited 374 patients on haemodialysis and 1571 reference patients with a mean post\u2010SVR<jats:sub>12<\/jats:sub> follow\u2010up of 4.7 and 6.1\u00a0years. All haemodialysis patients who achieved SVR<jats:sub>12<\/jats:sub> also achieved SVR<jats:sub>24<\/jats:sub>. The incidence rates of HCV reinfection were 0.23 per 100 PYs (95% confidence interval [CI]: 0.09\u20100.59) in haemodialysis patients and 0.16 per 100 PYs (95% CI: 0.10\u20100.26) in the reference group. The risk of HCV reinfection in patients on haemodialysis was comparable to that in the reference patients (hazard ratio [HR]: 1.39; 95% CI: 0.44\u20104.38, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.57).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of HCV reinfection in patients on haemodialysis who achieve SVR<jats:sub>12<\/jats:sub> is low and comparable to that in the low\u2010risk general population. HCV microelimination in this special population is feasible once universal screening and scaled\u2010up treatment are implemented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16697","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T08:01:57Z","timestamp":1636790517000},"page":"434-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hepatitis C virus reinfection in patients on haemodialysis after achieving sustained virologic response with antiviral treatment"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-9707","authenticated-orcid":false,"given":"Chen\u2010Hua","family":"Liu","sequence":"first","affiliation":[{"name":"Taipei Taiwan"},{"name":"Yunlin 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