{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:38Z","timestamp":1790744558922,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have examined the efficacy of gastric peroral endoscopic myotomy (G\u2010POEM) for gastroparesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the mid\u2010term efficacy of G\u2010POEM by meta\u2010analysis of studies with a minimum 1\u00a0year of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed several databases from inception to 10 June 2021 to identify studies that evaluated the efficacy of G\u2010POEM in refractory gastroparesis, and had at least 1\u00a0year of follow\u2010up. Our outcomes of interest were clinical success at 1\u00a0year, adverse events, difference in mean pre\u2010 and 1\u00a0year post\u2010procedure Gastroparesis Cardinal Symptom Index (GCSI) score, and difference in mean pre\u2010 and post\u2010procedure EndoFLIP measurements. We analysed data using a random\u2010effects model and assessed heterogeneity by\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 10 studies comprising 482 patients. Pooled rates (95% CI) of clinical success at 1\u00a0year and adverse events were 61% (49%, 71%) and 8% (6%, 11%), respectively. Mean GCSI at 1\u00a0year post\u2010procedure was significantly lower than pre\u2010procedure; mean difference (MD) (95% CI) \u22121.4 (\u22121.9, \u22120.9). Mean post\u2010procedure distensibility index was significantly higher than pre\u2010procedure in the clinical success group at 40 and 50\u00a0mL volume distension; standardised mean difference (95% CI) 0.82 (0.07, 1.64) and 0.91 (0.32, 1.49), respectively. In the clinical failure group, there was no significant difference between mean pre\u2010 and post\u2010procedure EndoFLIP measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>G\u2010POEM is associated with modest clinical success at 1\u00a0year. Additional studies with longer follow\u2010up are required to evaluate its longer\u2010term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16725","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:11:44Z","timestamp":1638400304000},"page":"168-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Systematic review with meta\u2010analysis: one\u2010year outcomes of gastric peroral endoscopic myotomy for refractory gastroparesis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6842-506X","authenticated-orcid":false,"given":"Faisal","family":"Kamal","sequence":"first","affiliation":[{"name":"Division of Gastroenterology University of California\u2010San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Lee\u2010Smith","sequence":"additional","affiliation":[{"name":"Mulford Health Sciences Library University of Toledo  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toledo  Toledo Ohio USA"},{"name":"Division of Gastroenterology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashu","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toledo  Toledo Ohio 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