{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:23:41Z","timestamp":1787725421886,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","award":["#54873"],"award-info":[{"award-number":["#54873"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007602","name":"Programme Grants for Applied Research","doi-asserted-by":"publisher","award":["RP\u2010PG\u20100616\u201020008"],"award-info":[{"award-number":["RP\u2010PG\u20100616\u201020008"]}],"id":[{"id":"10.13039\/501100007602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In 2017, Tayside, a region in the East of Scotland, rapidly scaled\u2010up Hepatitis C Virus (HCV) outreach and treatment among People Who Inject Drugs (PWID) using novel community care pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to determine treatment outcomes for PWID during the scale\u2010up against pre\u2010determined targets; and assess re\u2010infection, mortality, and post\u2010treatment follow up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HCV treatment was delivered in community pharmacies, drug treatment centres, nurse\u2010led outreach clinics, prisons, and needle exchanges, alongside conventional hospital care. We retrospectively analysed clinical outcomes and compared pathways using logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 800 estimated HCV\u2010infected PWID, 718 (90%) were diagnosed. 713 treatments commenced among 662 (92%) PWID, delivering 577 (81%) Sustained Virologic Responses (SVR). SVR was 91% among those who attended for testing. Forty\u2010six individuals were treated more than once. Needle exchanges and community pharmacies initiated 49% of all treatments. Regression analyses implied pharmacies had superior follow\u2010up, but there was no difference in likelihood of achieving SVR in community pathways relative to hospital care. Re\u2010infection occurred 39 times over 256.57 person years (PY), yielding a rate of 15.20 per 100 PY (95% CI 10.81\u201020.78). 54 deaths occurred (29 drug related) over 1,553.04 PY, yielding a mortality rate of 3.48 per 100 PY (95% CI 2.61\u20104.54). Drug\u2010related mortality was 1.87 per 100 PY (95% CI 1.25\u20102.68).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rapid HCV treatment scale\u2010up to PWID in community settings, whilst maintaining high SVR, is achievable. However, other interventions are required to minimise re\u2010infection; reduce drug\u2010related deaths; and improve post\u2010SVR follow\u2010up testing regionally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16728","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T04:16:14Z","timestamp":1638936974000},"page":"568-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Real\u2010world outcomes of rapid regional hepatitis C virus treatment scale\u2010up among people who inject drugs in Tayside, Scotland"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-7712","authenticated-orcid":false,"given":"Christopher J.","family":"Byrne","sequence":"first","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee School of Medicine Ninewells Hospital  Dundee UK"},{"name":"Tayside Clinical Trials Unit University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Beer","sequence":"additional","affiliation":[{"name":"Tayside Clinical Trials Unit University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Inglis","sequence":"additional","affiliation":[{"name":"Tayside Clinical Trials Unit University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-2295","authenticated-orcid":false,"given":"Emma","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee School of Medicine Ninewells Hospital  Dundee UK"},{"name":"Department of Gastroenterology Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-2388","authenticated-orcid":false,"given":"Andrew","family":"Radley","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee School of Medicine Ninewells Hospital  Dundee UK"},{"name":"Directorate of Public Health National Health Service Tayside  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-523X","authenticated-orcid":false,"given":"David J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Public Health Scotland  Glasgow UK"},{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-459X","authenticated-orcid":false,"given":"Matthew","family":"Hickman","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-6758","authenticated-orcid":false,"given":"Sharon","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Public Health Scotland  Glasgow UK"},{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-4476","authenticated-orcid":false,"given":"John F.","family":"Dillon","sequence":"additional","affiliation":[{"name":"Division of Molecular and Clinical Medicine University of Dundee School of Medicine Ninewells Hospital  Dundee UK"},{"name":"Department of Gastroenterology Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Health Sector Strategy on Viral Hepatitis 2016\u20132021: Towards Ending Viral Hepatitis","author":"World Health Organization"},{"key":"e_1_2_9_3_1","unstructured":"Evaluating Treatment as Prevention Among People Who Inject Drugs in Dundee for HCV. 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