{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:30:09Z","timestamp":1790515809019,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Venesection is the key therapy in haemochromatosis, but it remains controversial in hyperferritinaemia with moderate iron accumulation. There is substantial evidence that the results of\n                      <jats:italic>HFE<\/jats:italic>\n                      genotyping are routinely misinterpreted, while elevated serum ferritin has become more frequent in recent years in white adult populations following the increase of obesity and metabolic traits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To examine the reasons for prescribing venesection in 1,059 French patients during the period 2012\u20102015, determine the true prevalence of\n                      <jats:italic>HFE<\/jats:italic>\n                      \u2010related haemochromatosis, and compare iron overload profiles between haemochromatosis and non\u2010haemochromatosis patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Only 258 of the 488 patients referred for haemochromatosis had the p.[Cys282Tyr];[Cys282Tyr] disease causative genotype (adjusted prevalence: 24.4%). Of the 801 remaining patients, 112 (14.0%) had the debated p.[Cys282Tyr];[His63Asp] compound heterozygote genotype, 643 (80.3%) had central obesity, 475 (59.3%) had metabolic syndrome (MetS) and 93 (11.6%) were heavy drinkers. The non\u2010haemochromatosis patients started therapeutic venesection 9\u00a0years later than haemochromatosis patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Despite similar serum ferritin values, they had lower transferrin saturation (41.1% vs 74.3%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), lower amounts of iron removed by venesection (1.7 vs 3.2\u00a0g;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and lower hepatic iron concentrations (107 vs 237\u00a0\u00b5mol\/g;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Haemochromatosis is over\u2010diagnosed and is no longer the main reason for therapeutic venesection in France. Obesity and other metabolic abnormalities are frequently associated with mild elevation of serum ferritin, the MetS is confirmed in ~50% of treated patients. There is a minimal relationship between serum ferritin and iron overload in non\u2010p.Cys282Tyr homozygotes. Our observations raise questions about venesection indications in non\u2010haemochromatosis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16775","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T23:04:33Z","timestamp":1644015873000},"page":"1016-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of\n                    <i>HFE<\/i>\n                    \u2010related haemochromatosis and secondary causes of hyperferritinaemia and their association with iron overload in 1059 French patients treated by venesection"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-7280","authenticated-orcid":false,"given":"G\u00e9rald","family":"Le Gac","sequence":"first","affiliation":[{"name":"Univ Brest, Inserm, EFS, UMR1078  Brest France"},{"name":"CHRU de Brest  Brest France"},{"name":"Labex GR\u2010Ex  Paris 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