{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:30:55Z","timestamp":1782451855598,"version":"3.54.5"},"reference-count":80,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Non\u2010alcoholic steatohepatitis (NASH) is the most common cause of liver disease. However, there is lack of comparison of efficacy between different NASH drug classes. We conducted a network meta\u2010analysis evaluating drug classes through comparing histological outcomes and targets of drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>Medline, EMBASE and CENTRAL were searched for randomised controlled trials evaluating NASH drugs in biopsy\u2010proven NASH patients. Primary outcomes included NASH resolution without worsening of fibrosis, at least 2\u2010point reduction in Non\u2010alcoholic fatty liver disease Activity Score (NAS) without worsening of fibrosis and at least 1\u2010point reduction in fibrosis. Treatments were classified into inflammation, energy, bile acid and fibrosis modulators. The analysis was conducted with Bayesian network model and surface under the cumulative ranking curve (SUCRA) analysis. Among 49 included trials, treatments modulating energy (Risk ratio (RR): 1.92, Credible intervals (Crl): 1.59\u20102.34) were most likely to achieve NASH resolution followed by treatments modulating fibrosis (RR 1.66, Crl: 0.65\u20104.50), bile acids (RR: 1.37, Crl: 0.99\u20101.92) and inflammation (RR: 1.00, Crl: 0.75\u20101.33). Energy and bile acids modulation were effective in at least 2\u2010point NAS reduction without worsening of fibrosis (RR: 1.52, Crl 1.30\u20101.77; RR: 1.69, Crl 1.41\u20102.03) and at least 1\u2010point reduction in fibrosis (RR: 1.26, Crl:1.05\u20101.49; RR: 1.54, Crl: 1.20\u20101.97).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This network analysis demonstrates the relative superiority of drugs modulating energy pathways and bile acids in NASH treatment. This guides the development and selection of drugs for combination therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16808","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T06:08:35Z","timestamp":1647238115000},"page":"1076-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Meta\u2010analysis: analysis of mechanistic pathways in the treatment of\n                    <scp>non\u2010alcoholic<\/scp>\n                    steatohepatitis. 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