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Optimal utilisation of therapeutic strategies to prevent and control the complications of cirrhosis are central to improving clinical and patient\u2010reported outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a narrative review of the literature focusing on the most recent advances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We review the aetiology\u2010focused therapies that can prevent cirrhosis and its complications. These include anti\u2010viral therapies, psychopharmacological therapy for alcohol\u2010use disorder, and the current landscape of clinical trials for non\u2010alcoholic steatohepatitis. We review the current standard of care and latest developments in the management of hepatic encephalopathy (HE), ascites and hepatorenal syndrome. We evaluate the promise and drawbacks of chemopreventative therapies that have been examined in trials and observational studies which may reduce the risk of hepatocellular carcinoma and cirrhosis complications. Finally, we examine the therapies which address the non\u2010pain symptoms of cirrhosis including pruritis, muscle cramps, sexual dysfunction and fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The improvement of clinical and patient\u2010reported outcomes for patients with cirrhosis is possible by applying evidence\u2010based pharmacotherapeutic approaches to the prevention and treatment of cirrhosis complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16831","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T09:13:55Z","timestamp":1646212435000},"page":"1099-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Review article: current and emerging therapies for the management of cirrhosis and its complications"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-1515","authenticated-orcid":false,"given":"Elliot B.","family":"Tapper","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-9374","authenticated-orcid":false,"given":"Nneka N.","family":"Ufere","sequence":"additional","affiliation":[{"name":"Liver Center, Division of Gastroenterology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Q.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Health System  Singapore"},{"name":"NAFLD Research Center Division of Gastroenterology and Hepatology. University of California at San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-9991","authenticated-orcid":false,"given":"Rohit","family":"Loomba","sequence":"additional","affiliation":[{"name":"NAFLD Research Center Division of Gastroenterology and Hepatology. 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