{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:28:44Z","timestamp":1789576124848,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Extra\u2010intestinal manifestations (EIMs) are a common complication of inflammatory bowel diseases (IBD), affecting up to half of the patients. Despite their high prevalence, information on standardised definitions, diagnostic strategies, and treatment targets is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As a starting point for a national EIM study network, an interdisciplinary expert panel of 12 gastroenterologists, 4 rheumatologists, 3 ophthalmologists, 6 dermatologists, and 4 patient representatives was assembled. Modified Delphi consensus methodology was used. Fifty\u2010four candidate items were derived from the literature review and expert opinion focusing on five major EIMs (erythema nodosum, pyoderma gangrenosum, uveitis, peripheral arthritis, and axial arthritis) were rated in three voting rounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For use in a clinical practice setting and as part of the creation of a prospective registry of patients with EIMs, the panel developed definitions for erythema nodosum, pyoderma gangrenosum, uveitis, peripheral arthritis, and axial arthritis; identified the appropriate and optimal subspecialists to diagnose and manage each; provided methods to monitor disease course; offered guidance regarding monitoring intervals; and defined resolution and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consensus criteria for appropriate and optimal means of diagnosing and monitoring five EIMs have been developed as a starting point to inform clinical practice and future trial design. Key findings include straightforward diagnostic criteria, guidance regarding who can appropriately and optimally diagnose each, and monitoring options that include patient and physician\u2010reported outcomes. These findings will be used in a national multicenter study network to optimise the management of EIMs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16853","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T05:37:35Z","timestamp":1647063455000},"page":"1179-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A United States expert consensus to standardise definitions, follow\u2010up, and treatment targets for extra\u2010intestinal manifestations in inflammatory bowel disease"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8397-3670","authenticated-orcid":false,"given":"Katherine","family":"Falloon","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-1821","authenticated-orcid":false,"given":"Ashwin N.","family":"Ananthakrishnan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-8796","authenticated-orcid":false,"given":"Edward\u00a0L.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of North Carolina  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-249X","authenticated-orcid":false,"given":"Jean\u2010Frederic","family":"Colombel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond\u00a0K.","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia S.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Maryland  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mayo Clinic Arizona  Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of North Carolina  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-9643","authenticated-orcid":false,"given":"Sara","family":"Horst","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hou","sequence":"additional","affiliation":[{"name":"Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center &amp; Section of Gastroenterology and Hepatology Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elaine","family":"Husni","sequence":"additional","affiliation":[{"name":"Department of Rheumatologic and Immunologic Disease Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kroshinsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine A.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Careen Y.","family":"Lowder","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Cole Eye Institute  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Martin","sequence":"additional","affiliation":[{"name":"Dr. George Martin Dermatology Associates  Kihei HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deep","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology New York Eye and Ear Infirmary of Mount Sinai, Department of Ophthalmology New York University Langone Health  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schocket","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Maryland  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette C.","family":"Siaton","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology University of Maryland  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Vedak","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-1568","authenticated-orcid":false,"given":"Florian","family":"Rieder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.343"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105085(09)61629\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy222.534"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.387"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2001.03756.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i34.12269"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1574569"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001187"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjx002.056"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2003.07581.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy065"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjv213"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy191"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjx008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010322129"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.06.025"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjw199"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010019\u201005999\u20104"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjaa260"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjz095"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620950093"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.074815"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20852"},{"key":"e_1_2_10_27_1","volume-title":"The Delphi Method: An Experimental Study of Group Opinion","author":"Dalkey NC","year":"1969"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1287\/mnsc.9.3.458"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijforecast.2010.05.004"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20105073(73)90052\u20104"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5980"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16401"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(21)00297\u20101"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.16853","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:44:37Z","timestamp":1692989077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/apt.16853"],"URL":"https:\/\/doi.org\/10.1111\/apt.16853","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,11]]},"assertion":[{"value":"2021-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}