{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:01:32Z","timestamp":1791270092065,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS\u2010789611"],"award-info":[{"award-number":["SLS\u2010789611"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201002002"],"award-info":[{"award-number":["2020\u201002002"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201002021"],"award-info":[{"award-number":["2020\u201002021"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>To estimate familial aggregation of inflammatory bowel disease (IBD), we performed a nationwide, case\u2013control study and examined the odds for patients with IBD (vs controls) to have a first\u2010degree relative (FDR) with IBD, by age of diagnosis, type of family history and IBD subtype. To assess the incidence of future IBD in relatives of incident IBD patients, we performed a cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individuals diagnosed with IBD (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a050,667) between 2003 and 2017 with at least one FDR were identified from Swedish national registers and compared to general population controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0506,720) with at least one FDR. We used logistic regression to calculate adjusted odds ratios (ORs) and Cox regression to estimate hazard ratios (HRs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to controls, IBD cases more often had a mother (3.0% vs 0.9%, OR\u00a0=\u00a03.5; 95% CI: 3.3\u20133.7), father (2.9% vs 0.8%, OR\u00a0=\u00a03.5; 95% CI: 3.3\u20133.7), full sibling (5.3% vs 1.5%, OR\u00a0=\u00a03.6; 95% CI: 3.4\u20133.8) and child (2.4% vs 0.9%, OR\u00a0=\u00a02.6; 95% CI: 2.4\u20132.8) with IBD. The strength of association increased with the number of affected FDRs and was modified by subtype of IBD and age of diagnosis. Highest ORs were observed for paediatric IBD among paediatric\u2010onset Crohn\u2019s disease (OR\u00a0=\u00a010.6; 95% CI: 8.2\u201313.5) and paediatric\u2010onset ulcerative colitis (OR\u00a0=\u00a08.4; 95% CI: 6.4\u201310.9) cases. The 10\u2010year cumulative incidence of IBD was 1.7% in full\u2010siblings of incident IBD patients vs 0.4% among full\u2010siblings of reference individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The variations in the strength of familial IBD and future risk of IBD in FDRs support differences in genetic predisposition and call for targeted approaches in potential screening programmes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.16938","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T01:16:52Z","timestamp":1650676612000},"page":"491-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Age determines the risk of familial inflammatory bowel disease\u2014A nationwide study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-7234","authenticated-orcid":false,"given":"Jonas","family":"Halfvarson","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine and Health, \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5602","authenticated-orcid":false,"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Pediatrics \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"Department of Medicine Columbia University College of Physicians and Surgeons New York City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bresso","sequence":"additional","affiliation":[{"name":"Center for Digestive Diseases Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Medicine Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Askling","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicine Solna, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Department Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division Department of Medicine Solna, Karolinska Institutet Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital Stockholm 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