{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:40:37Z","timestamp":1789000837180,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Keverprazan is a novel potassium\u2010competitive acid blocker (P\u2010CAB) with a strong acid\u2010suppressive capacity that may provide clinical benefit in acid\u2010related diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to explore the non\u2010inferior efficacy and safety of keverprazan to lansoprazole in treating erosive oesophagitis (EO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a phase III, randomised, double\u2010blind multicentre study. Patients were randomised to receive keverprazan 20\u2009mg once daily or lansoprazole 30\u2009mg once daily for 4\u20138\u2009weeks. EO healing rates and adverse events (AEs) were compared between the keverprazan group and the lansoprazole group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 238 patients comprised the full analysis set (FAS) while 221 patients comprised the per\u2010protocol set (PPS). For FAS analysis, the EO healing rates at week 8 were 95.8% (114\/119) and 89.9% (107\/119) for keverprazan and lansoprazole respectively. For PPS analysis, the EO healing rates at week 8 were 99.1% (110\/111) and 92.7% (102\/110) for keverprazan and lansoprazole respectively. Non\u2010inferiority of keverprazan compared with lansoprazole according to EO healing rates at 8\u2009weeks was demonstrated in both FAS (difference: 5.8% [95% CI: \u22120.6% to 12.3%]; <jats:italic>p<\/jats:italic>\u00a0=\u20090.081) and PPS (difference: 6.1% [95% CI: 1.1%\u201311.2%]; <jats:italic>p<\/jats:italic>\u00a0=\u20090.018) analysis. Drug\u2010related AEs were reported in 34.5% (41\/119) patients of the keverprazan group and 25.2% (30\/119) patients of the lansoprazole group with no significant difference (<jats:italic>p<\/jats:italic>\u00a0=\u20090.156). No severe AE happened in the keverprazan group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated the non\u2010inferior efficacy of keverprazan to lansoprazole in treating EO. The incidences of drug\u2010related AEs were comparable between keverprazan and lansoprazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16959","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T04:05:00Z","timestamp":1651637100000},"page":"1524-1533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The efficacy and safety of keverprazan, a novel potassium\u2010competitive acid blocker, in treating erosive oesophagitis: a phase <scp>III<\/scp>, randomised, double\u2010blind multicentre study"],"prefix":"10.1111","volume":"55","author":[{"given":"Songfeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of 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