{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:16:02Z","timestamp":1790745362904,"version":"4.1.0"},"reference-count":107,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol\u2010associated hepatitis is an acute manifestation of alcohol\u2010associated liver disease (ALD) and is associated with 30%\u201340% mortality at 28\u2009days. Abstinence and corticosteroids are the mainstays of treatment, but the latter only improves short\u2010term mortality, so new and improved therapies remain an unmet need.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim was to review the pathophysiology of alcohol\u2010associated hepatitis and how various targets can be used by current and emerging therapies as treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A thorough literature review was conducted on acute alcohol\u2010associated hepatitis, current therapies and therapies under investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With the increasing prevalence of alcohol use disorder and ALD, the burden of alcohol\u2010associated hepatitis is also expected to rise. The current understanding of alcohol\u2010associated hepatitis pathophysiology has led to clinical trials of several therapies involving IL\u20101 antagonism, modification of the gut microbiome and liver regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Corticosteroid therapy for alcohol\u2010associated hepatitis is restricted in its applicability and has limited efficacy. Developing multidisciplinary, patient\u2010centred care models based on digital health technologies, in combination with continued discovery of novel therapies using multiomics data and computational biology techniques will be necessary to tackle the increasing burden of alcohol\u2010associated hepatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16969","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T08:09:02Z","timestamp":1652515742000},"page":"28-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Review article: current and emerging therapies for acute alcohol\u2010associated hepatitis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-488X","authenticated-orcid":false,"given":"Puru","family":"Rattan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31310\u20102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6939a6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.22942"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.10.030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32067"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32272"},{"key":"e_1_2_10_8_1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0805786"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29887"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16461"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(20)30062\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000161"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30369"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15376"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.1162"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5260.1113"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100643\u20105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025392\u2010y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.042"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.08.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3417"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712191"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2901"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30583"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30996"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2004.07.008"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30326\u20107"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agz036"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308331110"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100014\u20107"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010018\u20100099\u20101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(02)00599\u20103"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.013"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31256"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024843\u2010w"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100466"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31759"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010324295"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2009.02521.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12427"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90401-8"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010110\u20109\u2010685"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412278"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.011"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.018"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30866"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.019"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21607"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/43.2.213"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607195019004258"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.12.022"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.038"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.11.039"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195608302550901"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00350.2009"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00442.2014"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105703"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13586"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.009"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30451\u20100"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.015"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.6536"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16143"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25681"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2008.08.057"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.20206"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/GAST.2000.20189"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.014"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.10.010"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60777"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3892\/MMR.2019.10439"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29144"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2018.01.007"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(18)33618\u20107"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S230613"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101742\u2010x"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000458"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.029"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S35227"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.035"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2018.06.012"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30516"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31046"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25551"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101214"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.06.006"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.01.040"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i16.4975"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1244"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31033"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.048"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2003"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.1750101"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000527\u20100"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(18)30303\u20101"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13787"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1192\/BJP.2018.13"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61814\u20105"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32329"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2015.04.013"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.11.039"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14756"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31042"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.026"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.16969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T04:27:38Z","timestamp":1692246458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,14]]},"references-count":107,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/apt.16969"],"URL":"https:\/\/doi.org\/10.1111\/apt.16969","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,14]]},"assertion":[{"value":"2022-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}