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However, only 2.2% of CHB patients receive antiviral treatment globally. The complexity and strictness of the current clinical practice guidelines may limit expanding the treatment coverage for CHB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the impact of expanding treatment criteria on future disease burden in Korea, a hepatitis B virus (HBV) endemic country with high diagnostic rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>Dynamic country\u2010level data were used to estimate the HCC incidence, overall mortality and economic impact of three incremental scenarios compared to the base case in Korea through 2035.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2020, 1,409,000 CHB cases were estimated, with the majority born before 1995. All scenarios assumed treating 70% of eligible individuals. The first scenario removed viral load restrictions in cirrhotic patients, which would avert 13,000 cases of HCC and save 11,800 lives. The second scenario, lowering the alanine aminotransferase (ALT) level restriction to the upper limit of the normal in non\u2010cirrhotic patients, would avert 26,700 cases of HCC and save 23,300 lives. The last scenario removed the restriction by ALT and HBeAg in treating non\u2010cirrhotic individuals with a viral load of \u22652000\u2009IU\/ml, which would avert 43,300 cases of HCC and save 37,000 lives. All scenarios were highly cost\u2010effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simplifying and expanding treatment eligibility for CHB would save many lives and be highly cost\u2010effective when combined with high diagnostic rates. These dynamic country\u2010level data may provide new insights for their global application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17052","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T03:53:23Z","timestamp":1653537203000},"page":"519-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Impact of expanding hepatitis B treatment guidelines: A modelling and economic impact analysis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-577X","authenticated-orcid":false,"given":"Young\u2010Suk","family":"Lim","sequence":"first","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-4624","authenticated-orcid":false,"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-8663","authenticated-orcid":false,"given":"Jae\u2010Jun","family":"Shim","sequence":"additional","affiliation":[{"name":"Kyung Hee University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homie","family":"Razavi","sequence":"additional","affiliation":[{"name":"CDA Foundation  Lafayette Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-1053","authenticated-orcid":false,"given":"Devin","family":"Razavi\u2010Shearer","sequence":"additional","affiliation":[{"name":"CDA Foundation  Lafayette Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-5554","authenticated-orcid":false,"given":"Dong Hyun","family":"Sinn","sequence":"additional","affiliation":[{"name":"Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_8_3_1","volume-title":"Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021","author":"World Health Organization","year":"2021"},{"key":"e_1_2_8_4_1","volume-title":"Interim guidance for country validation of viral hepatitis elimination","author":"World Health Organization","year":"2021"},{"key":"e_1_2_8_5_1","unstructured":"Foundation C.Polaris Observatory \u2010 Maps \u2010 Elimination.2021;https:\/\/cdafound.org\/dashboard\/polaris\/maps.html. 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