{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:22:50Z","timestamp":1792592570778,"version":"4.5.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with liver diseases have complicated haemostatic alternations, resulting in both bleeding and thromboembolic complications, which cannot be sufficiently evaluated by conventional coagulation tests (CCTs), such as platelet count or prothrombin time. Thromboelastography (TEG) is a whole blood viscoelastic test which globally reflects changes in the haemostatic system, and its utility in evaluating patients with liver disease is increasingly recognised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review the current evidence and clinical significance of TEG in liver diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature regarding TEG and liver diseases was comprehensively searched.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TEG is associated closely with the severity and aetiology of liver disease, the course of infection and the risk of bleeding and death, but not the risk of portal venous system thrombosis. Additionally, TEG\u2010guided transfusion protocols can significantly decrease the requirement for blood products compared to those guided by CCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TEG can reflect the haemostatic status of liver diseases more comprehensively than CCTs. It has the potential to assess the severity of liver diseases, predict the risk of bleeding and death in patients with liver disease and guide blood product transfusion. Future studies should standardise the use of TEG for assessing disease severity and development of clinical events and guiding blood product transfusion in patients with liver diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17080","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T08:20:41Z","timestamp":1655194841000},"page":"580-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Review article: thromboelastography in liver diseases"],"prefix":"10.1111","volume":"56","author":[{"given":"Yanglan","family":"He","sequence":"first","affiliation":[{"name":"Department of Gastroenterology General Hospital of Northern Theater Command  Shenyang China"},{"name":"Postgraduate College China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahum","family":"M\u00e9ndez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Liver Research Unit Medica Sur Clinic &amp; Foundation and Faculty of Medicine National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-6739","authenticated-orcid":false,"given":"Xingshun","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23205"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2011"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-261891"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31646"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198509000-00008"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715475"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.070"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004192"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.019"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.19.13468-2"},{"key":"e_1_2_16_12_1","unstructured":"https:\/\/training.cochrane.org\/handbooks."},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2017.37.3.204"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.04.029"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01832-3"},{"key":"e_1_2_16_16_1","first-page":"513","article-title":"Potential applications of thromboelastography in patients with acute and chronic liver disease","volume":"8","author":"Stravitz RT","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09946-3"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1673372"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0012.7205"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20569"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.09.010"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12369"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.07.053"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15112"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2017.06.002"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05597-4"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001285"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80420-5"},{"key":"e_1_2_16_29_1","first-page":"S1","article-title":"The British Society of Gastroenterology, spring meeting. 25\u201027 March 1992. 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