{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:35:35Z","timestamp":1791599735089,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>NAFLD is increasing in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the recent trend and forecast the future global prevalence of paediatric NAFLD<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, Web of Science and Cochrane library databases from inception to 1 May 2021 for studies of children and adolescents (\u226421\u2009years) with NAFLD. Obesity was defined with weight at \u226595th percentile and overweight as 85th to &lt;95th percentile as per the Center for Disease Control BMI\u2010for\u2010age percentile cut\u2010offs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 3350 titles and abstracts, we included 74 studies (276,091 participants) from 20 countries\/regions. We included 14 studies in the general NAFLD prevalence analysis, yielding an overall prevalence of 7.40% (95% CI: 4.17\u201312.81) regardless of the diagnostic method, and 8.77% (95% CI: 3.86\u201318.72) by ultrasound. Among continents with more than one study, the prevalence of NAFLD was 8.53% (95% CI: 5.71\u201312.55) for North America, 7.01% (95% CI: 3.51\u201313.53) for Asia, and 1.65% (95% CI: 0.97\u20132.80) for Europe. NAFLD prevalence regardless of the diagnostic method was 52.49% (95% CI: 46.23\u201358.68, 9159 participants) and 39.17% (95% CI: 30.65\u201348.42, 5371 participants) among obese and overweight\/obese participants, respectively. For the general population, trend analysis from 2000 to 2017 indicates an increasing global prevalence of paediatric NAFLD from 4.62% to 9.02% at a yearly increase of 0.26%, whereas forecast analysis predicts a prevalence of 30.7% by 2040.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of paediatric NAFLD varies by region and is 52.49% overall among the obese population and 7.40% in the general population. It is predicted to reach 30.7% by 2040.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17096","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T08:58:45Z","timestamp":1655974725000},"page":"396-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Meta\u2010analysis: global prevalence, trend and forecasting of non\u2010alcoholic fatty liver disease in children and adolescents, 2000\u20132021"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-8645","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"},{"name":"Institute of Viruses and Infectious Diseases Nanjing University  Nanjing Jiangsu 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