{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:37:04Z","timestamp":1789043824979,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tenofovir alafenamide (TAF) may be preferable to other nucleos(t)ide analogues (NA) regarding outcomes against chronic hepatitis B virus (HBV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the longer term virological\/biochemical effectiveness of TAF and the renal safety of sequential therapy to TAF in real\u2010world settings<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multi\u2010centre, retrospective cohort study included consecutive adult patients who were switched from other NAs to TAF. We assessed the virological and biochemical responses up to 144 weeks. We performed sensitivity analyses for a subgroup with chronic kidney disease (CKD) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed the data of 391 patients with chronic hepatitis B previously treated with entecavir (ETV) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0174), tenofovir disoproxil fumarate (TDF) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0116) or an NA combination (<jats:italic>n<\/jats:italic>\u00a0=\u00a0101) for \u2265 24\u2009months. HBV DNA\u2009&lt;10\u00a0IU\/ml at week 144 was found for 99% of patients, regardless of prior NA regimen or HBV DNA level at baseline. For patients who switched from TDF to TAF, total, low\u2010density lipoprotein, high\u2010density lipoprotein cholesterol and triglycerides were significantly increased after the switch. Patients who switched from a nucleotide analogue to TAF had an improved estimated glomerular filtration rate, although the rate of hypophosphataemia (&lt;2.5\u00a0mg\/dl) remained 9.7% at week 144. The virological and biochemical responses of patients with CKD were similar to the overall results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Switching to TAF remained effective and safe for up to 3\u2009years. Given the increasing comorbidities related to ageing, it will be important to carefully follow the change in the lipid levels of patients with a prior TDF\u2010based regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17107","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T12:48:32Z","timestamp":1655988512000},"page":"713-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Switching to tenofovir alafenamide for nucleos(t)ide analogue\u2010experienced patients with chronic hepatitis B: week 144 results from a real\u2010world, multi\u2010centre cohort study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-3967","authenticated-orcid":false,"given":"Eiichi","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine Kyushu University Hospital  Fukuoka 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Medicine Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Medicine Kyushu Central Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"The Center for Liver Disease Shin\u2010Kokura Hospital  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyushu Medical Center, National Hospital Organization  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyushu Cancer Center  Fukuoka 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