{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:44Z","timestamp":1787013884942,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autoimmune hepatitis (AIH) may coexist with metabolic syndrome\u2010associated diseases (MSADs) given patients' inherent need for corticosteroid therapy, as well as general population trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To examine the impact of MSAD risk factors on AIH or its treatment, and\n                      <jats:italic>vice versa<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multi\u2010centre retrospective cohort study of 552 patients with AIH diagnosed between January 2000 and December 2019. Data relating to demographic factors, laboratory values, AIH medications and MSADs were collected at diagnosis and at 1\u2010 and 3\u2010year follow\u2010up. Statistical relationships were analysed and reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 552 patients in the study cohort (median age 50\u2009years, 76.1% female). All MSADs, including hypertension, dyslipidaemia, diabetes and a gain of BMI \u22653\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , increased within the AIH cohort over time. Initial treatment regimen impacted\n                      <jats:italic>de novo<\/jats:italic>\n                      diabetes but not other MSAD development. AIH biochemical remission was less frequent at 3\u2009years post\u2010diagnosis among patients with \u22651 MSAD. The incidence of new MSADs could be predicted by baseline factors in certain cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In the largest US\u2010based cohort of patients newly diagnosed with AIH, there was a considerable burden of pre\u2010existing and\n                      <jats:italic>de novo<\/jats:italic>\n                      MSADs that may affect AIH treatment outcomes. Identifying those at highest risk of co\u2010morbid MSADs allows for an individualised approach to management to reduce its long\u2010term sequelae in patients with AIH.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17191","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T05:05:25Z","timestamp":1660626325000},"page":"1183-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Autoimmune hepatitis and metabolic syndrome\u2010associated disease development: a U.S. cohort study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-740X","authenticated-orcid":false,"given":"Muhammad I.","family":"Jalal","sequence":"first","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Brahmbhatt","sequence":"additional","affiliation":[{"name":"Larkin Community Hospital Department of Gastroenterology and Hepatology  South Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Green","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine Division of Gastroenterology and Hepatology  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5605-8995","authenticated-orcid":false,"given":"Ethan M.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Division of Gastroenterology &amp; Hepatology  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-640X","authenticated-orcid":false,"given":"Craig","family":"Lammert","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine Division of Gastroenterology and Hepatology  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-0193","authenticated-orcid":false,"given":"Therese","family":"Bittermann","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Division of Gastroenterology &amp; Hepatology  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944717711379"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31065"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14548"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.157735"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0303"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12046"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022805"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010016\u20104213\u20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.046"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.07.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S247379"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168\u20108278(99)80297\u20109"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003100"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchy.2020.100061"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.732"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.05.002"},{"key":"e_1_2_10_25_1","unstructured":"National Diabetes Statistics Report | Diabetes | CDC. 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