{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:12:18Z","timestamp":1792098738684,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metabolic\u2010associated fatty liver disease (MAFLD) was proposed in 2020 to identify fatty liver disease associated with metabolic risks. Metabolic abnormalities with hepatitis C virus (HCV) and MAFLD frequently co\u2010exist. However, data on the co\u2010existence are still lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the prevalence and characteristics of metabolic profiles among a large cohort of patients with HCV infection\u00a0between 2007 and 2020 based on new diagnostic criteria<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 288,222 patients with chronic HCV infection with demographic data, laboratory parameters, and ultrasound from a web\u2010based registry of the National Committee for Control of Viral Hepatitis in Egypt from 2007 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the participants, 41.9% (95% CI: 41.69\u201342.05) met diagnostic criteria for MAFLD, with a significant increase in the period 2014\u20132020 compared to 2007\u20132013 (43.3% vs. 19%, respectively). Participants with MAFLD had a high prevalence of obesity, diabetes mellitus and hypertension. The prevalences increased significantly over time (obesity: 66.7% vs. 76.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01; diabetes mellitus: 14.6% vs. 31.5%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01; hypertension: 0.9% vs. 7.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01; prediabetes: 28.8% vs. 25.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01) for the periods 2007\u20132013 and 2014\u20132020, respectively. The percentage of advanced fibrosis by fibrosis\u20104 index (FIB\u20104) and NAFLD fibrosis score (NFS) was significantly higher in participants with MAFLD during 2014\u20132020 than during 2007\u20132013 (FIB\u20104; 18.4% vs. 8% and NFS; 17.1% vs. 7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MAFLD is highly prevalent in patients with HCV infection and has risen over time. This rising prevalence parallels the alarming rise in obesity, diabetes mellitus and hypertension. Early detection of metabolic dysfunction in patients with HCV infection is recommended to prevent MAFLD progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17233","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T06:19:13Z","timestamp":1664345953000},"page":"1581-1590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence and clinical characteristics of patients with metabolic dysfunction\u2010associated fatty liver disease with hepatitis C virus infection\u2014a population\u2010based study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-2533","authenticated-orcid":false,"given":"Dina","family":"Attia","sequence":"first","affiliation":[{"name":"Beni\u2010Suef University Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine  Beni Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-0130","authenticated-orcid":false,"given":"Shereen","family":"Abdel Alem","sequence":"additional","affiliation":[{"name":"Cairo University Department of Endemic Medicine, Faculty of Medicine  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa","family":"El\u2010Akel","sequence":"additional","affiliation":[{"name":"Cairo University Department of Endemic Medicine, Faculty of Medicine  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-798X","authenticated-orcid":false,"given":"Wael","family":"Abdel\u2010Razek","sequence":"additional","affiliation":[{"name":"Ain Shams University (MOH) Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Eslam","sequence":"additional","affiliation":[{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7989-5318","authenticated-orcid":false,"given":"Yasser","family":"Fouad","sequence":"additional","affiliation":[{"name":"Minia University Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-8972","authenticated-orcid":false,"given":"Imam","family":"Waked","sequence":"additional","affiliation":[{"name":"National Liver Institute Department of Hepatology  Shebeen el Kom 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