{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:36:41Z","timestamp":1791128201761,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tegoprazan is a novel potassium\u2010competitive acid blocker used to treat acid\u2010related disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare tegoprazan 25\u2009mg with lansoprazole 15\u2009mg as maintenance therapy in healed erosive oesophagitis (EE)<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase 3, double\u2010blind, multi\u2010centre study, patients with endoscopically confirmed healed EE were randomised 1:1 to receive tegoprazan 25\u2009mg or lansoprazole 15\u2009mg once daily for up to 24\u2009weeks. The primary efficacy endpoint was the endoscopic remission rate after 24\u2009weeks. The secondary efficacy endpoint was the endoscopic remission rate after 12\u2009weeks. Safety endpoints included adverse events, clinical laboratory results and serum gastrin and pepsinogen I\/II levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We randomised patients to tegoprazan 25\u2009mg (<jats:italic>n<\/jats:italic>\u00a0=\u00a0174) or lansoprazole 15\u2009mg (<jats:italic>n<\/jats:italic>\u00a0=\u00a0177). Most had mild EE (Los Angeles (LA) grade A: 57.3%, LA grade B: 37.3%). The endoscopic remission rate after 24\u2009weeks was 90.6% with tegoprazan and 89.5% with lansoprazole. Tegoprazan was not inferior to lansoprazole for maintaining endoscopic remission at 24\u2009weeks and 12\u2009weeks. In subgroup analysis, tegoprazan 25\u2009mg showed no significant difference in maintenance rate according to LA grade (<jats:italic>p<\/jats:italic>\u2009=\u00a00.47). The maintenance effect of tegoprazan was consistent in CYP2C19 extensive metabolisers (<jats:italic>p<\/jats:italic>\u2009=\u00a00.76). Increases in serum gastrin were not higher in tegoprazan\u2010treated than lansoprazole\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tegoprazan 25\u2009mg was non\u2010inferior to lansoprazole 15\u2009mg in maintenance of healing of mild EE. In this study, tegoprazan had a similar safety profile to lansoprazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17255","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:02:14Z","timestamp":1667206934000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Randomised clinical trial: comparison of tegoprazan and lansoprazole as maintenance therapy for healed mild erosive oesophagitis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-6577","authenticated-orcid":false,"given":"Yu Kyung","family":"Cho","sequence":"first","affiliation":[{"name":"Catholic Photomedicine Research Institute, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-3703","authenticated-orcid":false,"given":"Jae Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, Dongguk University College of Medicine  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-0362","authenticated-orcid":false,"given":"Hyun\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine, Wonju Christian Hospital  Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-1599","authenticated-orcid":false,"given":"Tae\u2010Oh","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University Haeundae Paik Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-882X","authenticated-orcid":false,"given":"Jung\u2010Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-3306","authenticated-orcid":false,"given":"Suck Chei","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wonkwang University Hospital  Iksan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-8159","authenticated-orcid":false,"given":"Jeong Seop","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University, Seoul Paik Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0721-0364","authenticated-orcid":false,"given":"Sang Kil","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, Severance Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-1678","authenticated-orcid":false,"given":"Sung Woo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-0597","authenticated-orcid":false,"given":"Sung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea  Uijeongbu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-5214","authenticated-orcid":false,"given":"Hye\u2010Kyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, Ewha Womans University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-3714","authenticated-orcid":false,"given":"Sang Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital  Hwaseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gab\u2010Jin","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine GangNeung Asan Hospital, College of Medicine, Ulsan University  Gangneung South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-6957","authenticated-orcid":false,"given":"Moo In","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-5859","authenticated-orcid":false,"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-1377","authenticated-orcid":false,"given":"Kwang Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Digestive Disease Center CHA Bundang Medical Center, CHA University  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-5571","authenticated-orcid":false,"given":"In Kyung","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konkuk University Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-7506","authenticated-orcid":false,"given":"Si Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-5354","authenticated-orcid":false,"given":"Ju Yup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keimyung University School of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-1923","authenticated-orcid":false,"given":"Soo Teik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jeonbuk National University Hospital  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-5296","authenticated-orcid":false,"given":"Poong\u2010Lyul","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center, Sungkyunkwan University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-0406","authenticated-orcid":false,"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seongnam and Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-0360","authenticated-orcid":false,"given":"Su Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University College of Medicine  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University Changwon Hospital  Changwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-5734","authenticated-orcid":false,"given":"Gwang Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University College of Medicine and Biomedical Research Institute, Pusan National University Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0850","authenticated-orcid":false,"given":"Kwang Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University Hospital, Ajou University School of Medicine  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-8123","authenticated-orcid":false,"given":"Sung Kook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University Hospital  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-5576","authenticated-orcid":false,"given":"Woon Geon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine\/Institute for Liver and Digestive Diseases  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6025-530X","authenticated-orcid":false,"given":"Oh Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1817385"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000200917"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15502"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18029"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18139"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15438"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16121"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15185"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15865"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16477"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200262080\u201000004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i14.1550"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.14\u2010144"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0349"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.5.642"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.1.54"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484217"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v9.i7.63"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.17255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:26:07Z","timestamp":1692311167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/apt.17255"],"URL":"https:\/\/doi.org\/10.1111\/apt.17255","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]},"assertion":[{"value":"2022-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}