{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:19:43Z","timestamp":1778570383182,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic hepatitis B virus (HBV) infection is a major cause of decompensated cirrhosis and liver cancer worldwide. Newborn HBV vaccination was implemented in Spain two decades ago, and potent oral antivirals entecavir and tenofovir were introduced around 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the clinical benefits of these interventions nationwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Including HBV as a diagnosis, we performed a retrospective study of all hospitalisations in Spain the Spanish National Registry of Hospital Discharges. Information was retrieved from 1997 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 73,939,642 nationwide hospital admissions during the study period, 129,634 (0.17%) included HBV as diagnosis. Their number doubled from 2007 to 2017 and the median age increased from 44 to 58\u2009years. Most HBV admissions recorded chronic hepatitis B. In\u2010hospital death occurred in 6.4%. Co\u2010infection with HIV or hepatitis C virus occurred in 11.9% and 23.3%, respectively. Patients with HIV\u2010HBV co\u2010infection had significantly greater mortality than individuals with HBV mono\u2010infection. The rate of HBV hospitalisations significantly increased over time with a transient drop around 2007, coincident with the arrival of new potent oral antivirals. Although the proportion of HBV hepatic decompensation events has declined, the rate of liver cancer continues to rise. The small subset of patients with hepatitis delta superinfection increasingly and disproportionately accounts for hepatic decompensation events and liver cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospital admissions of individuals with HBV infection are increasing in Spain. While hepatic decompensation events declined following the introduction of potent oral nucleos(t)ide therapy, HBV\u2010related liver cancer is rising. No benefit of oral antiviral therapies is seen on hepatitis delta.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17280","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T05:54:13Z","timestamp":1667368453000},"page":"540-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of potent nucleos(t)ide therapy on hepatitis B hospitalisations in Spain"],"prefix":"10.1111","volume":"57","author":[{"given":"Jos\u00e9\u2010Manuel","family":"Ramos\u2010Rincon","sequence":"first","affiliation":[{"name":"Internal Medicine Department General University Hospital of Alicante\u2010ISABIAL &amp; Miguel Hern\u00e1ndez University of Elche  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Pinargote\u2010Celorio","sequence":"additional","affiliation":[{"name":"Internal Medicine Department General University Hospital of Alicante\u2010ISABIAL &amp; Miguel Hern\u00e1ndez University of Elche  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"de Mendoza","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Puerta de Hierro Research Institute &amp; University Hospital  Majadahonda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Ramos\u2010Belinch\u00f3n","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Gregorio Mara\u00f1\u00f3n University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Regional Public Health Laboratory Hospital Isabel Zendal  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"UNIR Health Sciences School &amp; Medical Center  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Corral","sequence":"additional","affiliation":[{"name":"UNIR Health Sciences School &amp; Medical Center  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-5199","authenticated-orcid":false,"given":"Vicente","family":"Soriano","sequence":"additional","affiliation":[{"name":"UNIR Health Sciences School &amp; Medical Center  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31865-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2009.03.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13061032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp041507"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3795"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.06.002"},{"key":"e_1_2_9_10_1","volume-title":"Combating hepatitis B and C to reach elimination by 2030","author":"WHO","year":"2016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13350"},{"key":"e_1_2_9_12_1","first-page":"1078","article-title":"Servicios Sociales e Igualdad. Real decreto 69\/2015, de 6 febrero, por el que se regula el Registro de Actividad Sanitaria Especializada","volume":"35","author":"Sanidad Ministerio","year":"2015","journal-title":"Bolet\u00edn del Estado"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002508"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9091991"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112491"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003024"},{"key":"e_1_2_9_17_1","unstructured":"Ministerio de sanidad y Consumo.Metodolog\u00eda de la hospitalizaci\u00f3n en el Sistema Nacional de salud. Available online:http:\/\/www.mscbs.gob.es\/estadEstudios\/estadisticas\/docs\/metod_modelo_cmbd_pub.pdf(accessed April 15th 2022)"},{"key":"e_1_2_9_18_1","unstructured":"Spanish Statistics Institute. Available online:http:\/\/www.ine.es\/en\/index.htm(accessed on April 15th 2022)"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi5658"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810477"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30270-X"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0332-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00218-1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-091919-062728"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30249-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01374-X"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.021"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13708"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2006.00778.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049936120965027"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.10.052"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.17280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T14:40:57Z","timestamp":1692283257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/apt.17280"],"URL":"https:\/\/doi.org\/10.1111\/apt.17280","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}