{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:03:34Z","timestamp":1792415014507,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mortality benefits of vigorous leisure time physical activity (LTPA) among adults with NAFLD is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate association between LTPA and reduction in all\u2010cause mortality among adults with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used NHANES (1999\u20132006) self\u2010reported PA data for adults (\u226540\u2009years) with mortality follow\u2010up through December 31, 2015. US\u2010Fatty Liver Index in absence of secondary causes identified NAFLD. Moderate and vigorous LTPA were calculated by the 2018 PA Guidelines for Americans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NAFLD prevalence among 5211 adults (46.2% male; 75.8% white; mean age 53.2\u2009years) was 32.7%. Adults with NAFLD were less likely to report the recommended minimal PA (\u2265\u2009150\u2009min\/week, 55.5% vs 64.8%) or highly active PA (\u2265300\u2009min\/week, 39.2% vs 48.5%) compared to adults without NAFLD. Over a median follow\u2010up of 12.3\u2009years, 355 deaths among adults with NAFLD and 510 deaths among adults without NAFLD were registered. In the metabolic comorbidities\u2010adjusted model, adults with NAFLD who reported \u226550% of their total PA as vigorous activity had a 56% reduction in all\u2010cause mortality risk (HR:0.44, 95%CI: 0.25\u20130.76) and cancer\u2010specific mortality risk (HR: 0.21, 0.06\u20130.66) but not cardiac\u2010specific mortality (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) compared to adults with NAFLD who did not report any LTPA. This association remained significant even among adults with NAFLD who met the recommended minimal PA, among adults with NAFLD who reported any LTPA, and among adults with NAFLD who had metabolic abnormalities and in sensitivity analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Engaging in vigorous activity is beneficial for adults with NAFLD \u2010 especially those with metabolic abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17308","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T04:05:12Z","timestamp":1668571512000},"page":"709-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Vigorous physical activity provides protection against all\u2010cause deaths among adults patients with nonalcoholic fatty liver disease (<scp>NAFLD<\/scp>)"],"prefix":"10.1111","volume":"57","author":[{"given":"Austin","family":"Henry","sequence":"first","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Paik","sequence":"additional","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System  Falls Church Virginia USA"},{"name":"Center for Liver Disease, Department of Medicine Inova Fairfax Medical Campus  Falls Church Virginia USA"},{"name":"Medicine Service Line Inova Health System  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Austin","sequence":"additional","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System  Falls Church Virginia USA"},{"name":"Center for Liver Disease, Department of Medicine Inova Fairfax Medical 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