{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:19Z","timestamp":1790517439487,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The European consensus defined gastroparesis as a condition characterised by delayed gastric emptying (GE) in the absence of mechanical obstruction, with a symptom pattern of predominant nausea and\/or vomiting and overlapping postprandial distress syndrome (PDS). The distinction between patients with gastroparesis and those with functional dyspepsia (FD), another gastrointestinal condition characterised by predominant PDS or epigastric pain syndrome symptoms, is ongoing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the extent that symptom patterns may differentiate gastroparesis from FD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 637 patients from Leuven University Hospital in 2006\u20132021 who had upper gastrointestinal symptoms, underwent a GE test, and completed the Dyspepsia Symptom Severity (DSS) questionnaire. Patients were identified as with gastroparesis\u2010like symptoms (GPLS;\n                      <jats:italic>i.e<\/jats:italic>\n                      ., moderate to severe nausea with moderate to severe PDS) or FD symptoms (not fitting GPLS). We excluded patients aged &lt;18\u2009years, and those with diabetes, organic gastrointestinal disease or a history of abdominal surgeries. Demographic and clinical variables were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 545 patients, 238 reported GPLS and 307 reported FD symptoms. Those with GPLS had a significantly higher prevalence of delayed GE (half emptying time (T1\/2) \u2265109\u2009min) and lower body mass index than those with FD (33.2% vs 17.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.01; 19.9 vs 21.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.01, respectively). Among GPLS patients, those with delayed GE had higher DSS than those without (13.0 vs 12.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In tertiary care patients who reported gastroparesis or FD symptoms, the presence of delayed GE was associated with GPLS. In patients with GPLS, delayed GE was associated with higher symptom severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17330","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T08:11:42Z","timestamp":1673338302000},"page":"773-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of delayed gastric emptying in patients with gastroparesis\u2010like symptoms"],"prefix":"10.1111","volume":"57","author":[{"given":"I\u2010Hsuan","family":"Huang","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University of Leuven  Leuven Belgium"},{"name":"Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"Schol","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University of Leuven  Leuven Belgium"},{"name":"Department of Gastroenterology and Hepatology UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhu J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Global Evidence and Outcomes Takeda Development Center Americas, Inc.  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