{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:58:54Z","timestamp":1785473934026,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An unmet need remains for improved management in perianal fistulising Crohn's disease (pCD). Recently, local administration of adipose\u2010derived cells has shown promising results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the safety and feasibility of injection of stromal vascular fraction (SVF) with platelet\u2010rich plasma (PRP) in patients with pCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients \u2265\u200918\u2009years with pCD were included and underwent fistula curettage, SVF with PRP injection, and closure of the internal opening. The primary endpoint was safety at 12\u2009months. The secondary outcomes were complete radiological healing at 3\u00a0months (absence of fluid\u2010containing tracts on MRI) and partial and complete clinical response at 3 and 12\u2009months (closure of \u22651, respectively, all treated external opening(s)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients were included (35 [IQR 25\u201340]\u00a0years; 14 [56%] female); median CD duration 4 [IQR 2\u20138]\u00a0years. Twenty\u2010four (95%) patients had previously undergone fistula surgery. No adverse events were encountered at lipoharvesting sites. Two (8%) patients were readmitted to hospital and six (24%) underwent unplanned re\u2010interventions. Post\u2010operative MRI (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) showed complete radiological healing in nine (37.5%) patients. Partial clinical response was present in 48% (12\/25) at 3\u00a0months and in 68% (17\/25) at 12\u2009months, and complete clinical closure in five (20%) patients at 3\u00a0months and in 10 (40%) patients at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Injection with autologous SVF with PRP is feasible and safe in patients with treatment\u2010refractory pCD. Early complete radiological healing was observed in more than one\u2010third of patients, and clinical response in two\u2010thirds of patients at 12\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17347","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T19:08:50Z","timestamp":1672081730000},"page":"783-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Stromal vascular fraction with platelet\u2010rich plasma injection during surgery is feasible and safe in treatment\u2010refractory perianal fistulising Crohn's disease: A pilot study"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-4604","authenticated-orcid":false,"given":"Jeanine H. C.","family":"Arkenbosch","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oddeke","family":"van Ruler","sequence":"additional","affiliation":[{"name":"Department of Surgery IJsselland Hospital  Capelle aan den IJssel the Netherlands"},{"name":"Department of Surgery Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy S.","family":"Dwarkasing","sequence":"additional","affiliation":[{"name":"Department of Radiology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenny\u00a0M.","family":"Fuhler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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Janneke","family":"van der Woude","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz056"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"33","article-title":"Management of complex perianal Crohn's disease","volume":"30","author":"Aguilera\u2010Castro L","year":"2017","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i42.4821"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"1503","article-title":"American Gastroenterological Association Medical Position Statement: perianal Crohn's disease","volume":"125","author":"American Gastroenterological Association Clinical Practice 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