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We evaluated the risk of significant hepatic fibrosis in first\u2010degree relatives of Mexican American adults with HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional analysis of a prospective cohort of Mexican American probands with HCC and first\u2010degree relatives enrolled in the Hispanic Liver Cancer Cohort study. We evaluated the prevalence of hepatic fibrosis in first\u2010degree relatives, defined by liver stiffness measurement (LSM)\u2009&gt;=\u20097.0\u00a0kPa with transient elastography (TE). Secondary outcomes included the prevalence of definite hepatic steatosis, defined by controlled attenuation parameter &gt;=288\u2009dB\/m.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 70 probands diagnosed with HCC; 47% were female and the mean age was 62\u2009years (\u00b113\u2009years). Among 112 first\u2010degree relatives with a mean age of 43\u2009years (\u00b114\u2009years), 19 (17%) had significant fibrosis and 47 (42%) had definite hepatic steatosis, respectively. The prevalence of significant fibrosis was 20% in first\u2010degree relatives 40\u2009years of age or older. Regression analysis revealed that diabetes (OR 3.2, 95% CI: 1.1\u20139.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and aspartate aminotransferase &gt;=30\u2009units\/L (OR 4.0, 95% CI: 1.4\u201311.7, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) were predictors of significant fibrosis in first\u2010degree relatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using a well\u2010phenotyped familial cohort, we found that the prevalence of significant fibrosis and definite hepatic steatosis are high in first\u2010degree relatives of Mexican Americans with HCC, particularly those with diabetes, suggesting that this population may benefit from screening for liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17384","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T07:29:23Z","timestamp":1673422163000},"page":"378-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and factors associated with liver fibrosis among first\u2010degree relatives of Mexican Americans with hepatocellular carcinoma"],"prefix":"10.1111","volume":"57","author":[{"given":"Suzanne","family":"Sharpton","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Medicine, NAFLD Research Center University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuangda","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Medicine, NAFLD Research Center University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricki","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Department of Medicine, NAFLD Research Center University of California  San Diego, La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Genetics and Environmental Sciences University of Texas School of Public Health  Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Genetics and Environmental Sciences University of Texas School of Public Health  Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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