{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:50:06Z","timestamp":1791413406012,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00123"],"award-info":[{"award-number":["PI19\/00123"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00837"],"award-info":[{"award-number":["PI20\/00837"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Little is known about the extent of mitochondrial respiratory chain (MRC) activity dysfunction in patients with alcoholic hepatitis (AH). We aimed to assess the hepatic MRC activity in AH patients and its potential impact on the severity and prognosis of this life\u2010threatening liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MRC complexes were measured in liver biopsies of 98 AH patients (non\u2010severe, 17; severe, 81) and in 12 histologically normal livers (NL). Severity was assessed according to Maddrey's Index and MELD score. Corticosteroid response rate and cumulative mortality were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The activity of the five MRC complexes was markedly decreased in the liver of AH patients compared with that of NL subjects, being significantly lower in patients with severe AH than in those with non\u2010severe AH. There was a negative correlation between the activity of all MRC complexes and the severity of AH. Interestingly, only complex I and III activities showed a significant positive correlation with the corticosteroid response rate and a significant negative correlation with the mortality rate at all\u2010time points studied. In a multivariate regression analysis, besides the MELD score and the corticosteroid response rate, complex I activity was significantly associated with 3\u2010month mortality (OR\u00a0=\u00a06.03; <jats:italic>p<\/jats:italic>\u00a0=\u20090.034) and complex III activity with 6\u2010month mortality (OR\u00a0=\u00a04.70; <jats:italic>p<\/jats:italic>\u00a0=\u20090.041) in AH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that MRC activity is markedly decreased in the liver of AH patients, and, particularly, the impairment of MRC complexes I and III activity appears to have a significant impact on the clinical outcomes of patients with AH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17434","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T05:34:52Z","timestamp":1677821692000},"page":"1131-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mitochondrial respiratory chain activity is associated with severity, corticosteroid response and prognosis of alcoholic hepatitis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-1350","authenticated-orcid":false,"given":"Pablo","family":"Sol\u00eds\u2010Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Liver Research Unit, Hospital Universitario Santa Cristina Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa  Madrid Spain"},{"name":"Unidad M\u00e9dica Angloamericana  Madrid Spain"},{"name":"Gastroenterology and Hepatology Unit Hospital Universitario Santa Cristina  Madrid Spain"},{"name":"Facultad de Medicina Universidad Francisco de Vitoria  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"de la Flor\u2010Robledo","sequence":"additional","affiliation":[{"name":"Anesthesiology Department Hospital Universitario Severo Ochoa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Garc\u00eda\u2010Ru\u00edz","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Laboratory, Research Institute University Hospital \"12 de Octubre\". Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-879X","authenticated-orcid":false,"given":"Carlos E.","family":"Fern\u00e1ndez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Liver Research Unit, Hospital Universitario Santa Cristina Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-6210","authenticated-orcid":false,"given":"\u00c1gueda","family":"Gonz\u00e1lez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas Alberto Sols (Centro Mixto CSIC\u2010UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naina","family":"Shah","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-7799","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Bataller","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases, Division of Gastroenterology, Hepatology and Nutrition University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Liver Unit, Hospital Clinic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Departamento de Medicina, Facultat de Medicina Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-8706","authenticated-orcid":false,"given":"Carmelo","family":"Garc\u00eda\u2010Monz\u00f3n","sequence":"additional","affiliation":[{"name":"Liver Research Unit, Hospital Universitario Santa Cristina Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Sol\u00eds\u2010Herruzo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Laboratory, Research Institute University Hospital \"12 de Octubre\". Universidad Complutense  Madrid Spain"},{"name":"Departamento de Medicina, Facultad de Medicina Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i5.108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0014-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.469"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.042"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"620","article-title":"Effects of ethanol on the biogenesis of mitochondrial membranes and associated mitochondrial functions","volume":"23","author":"Rubin E","year":"1970","journal-title":"Lab Invest"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1978.tb05818.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90253-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40139-013-0021-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2021.1909051"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1340707"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-009-9158-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00426.2001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01736.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21372"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.016766"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.035"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33613"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90401-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20503"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.038"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21607"},{"issue":"8222","key":"e_1_2_10_23_1","first-page":"707","article-title":"Alcoholic liver disease: morphological manifestations. Review by an international group","volume":"1","year":"1981","journal-title":"Lancet"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2004.11.001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.172"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00487.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(93)90067-X"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70566-4"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32604"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23256"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.11.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040201"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.377374"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00270.2015"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00065.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840380426"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1024-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200411000-00003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100283"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01936.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17434","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.17434","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T10:54:28Z","timestamp":1702464868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/apt.17434"],"URL":"https:\/\/doi.org\/10.1111\/apt.17434","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]},"assertion":[{"value":"2022-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}