{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:42:32Z","timestamp":1774006952737,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente RC2021\/105\u201001"],"award-info":[{"award-number":["Ricerca Corrente RC2021\/105\u201001"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente RC2022\/105\u201001"],"award-info":[{"award-number":["Ricerca Corrente RC2022\/105\u201001"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term administration of TDF\/ETV in patients with HBV\u2010related compensated cirrhosis reduces HCC and decompensation events but the effect of this regimen on development\/regression of oesophageal varices (EV) is currently unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the risk of EV development\/progression in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 186 Caucasian HBV\u2010monoinfected compensated cirrhotics were enrolled in a long\u2010term cohort study from TDF\/ETV introduction. Upper GI endoscopies were performed according to Baveno recommendations. Primary endpoint was development\/progression of oesophageal\/gastric varices over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At TDF\/ETV start, median age was 61\u2009years, 80% males, 60% HBV\u2010DNA undetectable, 63% NUCs previously exposed, 73% normal ALT, 40% platelets &lt;150,000\/mmc and 25 (13%) with low\u2010risk varices (LRV). During 11\u2009years of antiviral therapy and 666 endoscopies performed, 9 patients either developed or had a progression of oesophageal or gastric varices with an 11\u2010year cumulative probability of 5.1% (95% CI 3\u201310%); no patient bled. Out of 161 patients without EV at baseline, the 11\u2010year probably was 4.5% with all varices developing within the first six years of treatment. In 25 patients with LRV at baseline, the 11\u2010year probability of progression or regression was 9.3% and 58%, respectively. Only baseline platelet count (HR 0.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) was associated with LRV development at multivariate analysis: platelet \u226490,000\/mmc (AUROC 0.70) had 98.1% specificity, 42.9% sensitivity, 50% PPV for LRV onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In compensated cirrhotic patients under long\u2010term effective TDF\/ETV treatment, the 11\u2010year risk of developing\/progressing EV is negligible, thus challenging the current endoscopic surveillance recommendations in patients without EV at baseline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17463","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T04:00:53Z","timestamp":1680062453000},"page":"1407-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term endoscopic surveillance in HBV compensated cirrhotic patients treated with Tenofovir or Entecavir for 11\u2009years"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0371-0035","authenticated-orcid":false,"given":"Elisa","family":"Farina","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-8803","authenticated-orcid":false,"given":"Alessandro","family":"Loglio","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-9575","authenticated-orcid":false,"given":"Giulia","family":"Tosetti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-4669","authenticated-orcid":false,"given":"Elisabetta","family":"Degasperi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Division of Hepatology San Giuseppe Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Gentile","sequence":"additional","affiliation":[{"name":"Division of Hepatology San Giuseppe Hospital  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation CRC \u201cA. 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