{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:26:43Z","timestamp":1784780803128,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK073974"],"award-info":[{"award-number":["U01DK073974"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK073975"],"award-info":[{"award-number":["U01DK073975"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK073983"],"award-info":[{"award-number":["U01DK073983"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK074007"],"award-info":[{"award-number":["U01DK074007"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK074008"],"award-info":[{"award-number":["U01DK074008"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK074035"],"award-info":[{"award-number":["U01DK074035"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK112193"],"award-info":[{"award-number":["U01DK112193"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Patients with gastroparesis and related disorders have symptoms including early satiety, postprandial fullness and bloating. Buspirone, a 5\u2010HT\n                      <jats:sub>1<\/jats:sub>\n                      receptor agonist, may improve fundic accommodation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine if buspirone treatment improves early satiety and postprandial fullness in patients with symptoms of gastroparesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This 4\u2010week multi\u2010centre clinical trial randomised patients with symptoms of gastroparesis and moderate\u2010to\u2010severe symptoms of fullness (Gastroparesis Cardinal Symptom Index [GCSI] early satiety\/postprandial fullness subscore [ES\/PPF]) to buspirone (10\u2009mg orally) or placebo three times per day. The primary outcome was a change in the ES\/PPF from baseline to 4\u2009weeks. The primary analysis was per protocol intention\u2010to\u2010treat ANCOVA of between\u2010group baseline vs. 4\u2010week differences (DoD) in ES\/PPF adjusted for baseline ES\/PPF. Results are reported using both nominal and Bonferroni (BF)\n                      <jats:italic>p<\/jats:italic>\n                      values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and conclusions<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010six patients (47 buspirone, 49 placeboes; 92% female, 50% delayed gastric emptying, 39% diabetic) were enrolled. There was no between\u2010groups difference in the 4\u2010week ES\/PPF primary outcome: \u22121.16\u2009\u00b1\u20091.25 (SD) on buspirone vs \u22121.03\u2009\u00b1\u20091.29 (SD) on placebo (mean DoD: \u22120.11 [95% CI: \u22120.68, 0.45];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.69). Buspirone performed better than placebo in patients with severe\u2010to\u2010very severe bloating at baseline compared to patients with none to moderate: (ES\/PPF DoD\u00a0=\u00a0\u22120.65 vs. 1.58,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>TX*GROUP<\/jats:sub>\n                      \u00a0=\u00a00.003;\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>BF<\/jats:sub>\n                      \u00a0=\u00a00.07). Among individual GCSI symptoms, only bloating appeared to improve with buspirone vs. placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with moderate\u2010to\u2010severe early satiety\/postprandial fullness and other symptoms of gastroparesis did not benefit from buspirone treatment to improve the ES\/PPF primary outcome compared with placebo. There was a suggestion of the benefit of buspirone in patients with more severe bloating.<\/jats:p>\n                    <jats:p>\n                      Trial Registration:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      NCT0358714285.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.17479","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T08:17:18Z","timestamp":1681373838000},"page":"1272-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Buspirone for early satiety and symptoms of gastroparesis: A\u00a0multi\u2010centre, randomised, placebo\u2010controlled, double\u2010masked trial (\n                    <scp>BESST<\/scp>\n                    )"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"Henry P.","family":"Parkman","sequence":"first","affiliation":[{"name":"Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine P.","family":"Yates","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Bulat","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Abell","sequence":"additional","affiliation":[{"name":"University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Koch","sequence":"additional","affiliation":[{"name":"Wake Forest University  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-0831","authenticated-orcid":false,"given":"Madhusudan","family":"Grover","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-5235","authenticated-orcid":false,"given":"Gianrico","family":"Farrugia","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Silver","sequence":"additional","affiliation":[{"name":"Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirah","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Wake Forest University  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubair","family":"Malik","sequence":"additional","affiliation":[{"name":"Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Miriel","sequence":"additional","affiliation":[{"name":"Johns Hopkins University  Baltimore Maryland 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