{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:05:42Z","timestamp":1784966742872,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite advances in ulcerative colitis (UC) therapies, a relatively undefined proportion of patients experience faecal incontinence (FI) in the absence of active inflammation. For this group, there remains a significant unmet need with a limited evidence base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to estimate the prevalence and impact of FI in UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective cross\u2010sectional study, patients with UC completed a series of validated questionnaires, including Rome IV FI criteria, an inflammatory bowel disease (IBD)\u2010specific FI questionnaire (ICIQ\u2010IBD), Hospital Anxiety and Depression Scale and IBD\u2010Control. UC remission was defined as faecal calprotectin (FCP) \u2264250\u2009\u03bcg\/g, or IBD\u2010control 8 score \u226513 and IBD\u2010Control\u2010VAS\u2009\u2265\u200985.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 255 patients with UC, overall, 20.4% fulfilled Rome IV criteria for FI. Rome IV FI prevalence did not differ between active and quiescent UC regardless of whether disease activity was defined by IBD\u2010Control scores \u00b1 FCP (<jats:italic>p<\/jats:italic>\u2009=\u20090.25), or objectively with FCP thresholds of 250\u2009\u03bcg\/g (<jats:italic>p<\/jats:italic>\u2009=\u20090.86) and 100\u2009\u03bcg\/g (<jats:italic>p<\/jats:italic>\u2009=\u20090.95). Most patients (75.2%) reported FI when in \u2018remission\u2019 and during \u2018relapse\u2019 (90.6%) according to ICIQ\u2010IBD. Those who reported FI according to both ICIQ\u2010IBD and Rome IV definitions had higher anxiety, depression and worse quality\u2010of\u2010life (QoL) scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In those with Rome IV FI, there was a strong correlation between FI symptom severity and impaired QoL (<jats:italic>r<\/jats:italic>\u2009=\u20090.809, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of FI in UC is high, even in remission, and associated with significant psychological distress, symptom burden and impaired QoL. These findings highlight the urgent need for further research and development of evidence\u2010based treatments for FI in UC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17502","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T05:25:37Z","timestamp":1680585937000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The prevalence and burden of Rome IV faecal incontinence in ulcerative colitis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-0616","authenticated-orcid":false,"given":"Dipesh H.","family":"Vasant","sequence":"first","affiliation":[{"name":"Neurogastroenterology Unit, Gastroenterology Department Wythenshawe Hospital, Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester 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Manchester  Manchester UK"},{"name":"Northern Care Alliance NHS Foundation Trust  Greater Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-6251","authenticated-orcid":false,"given":"Jimmy K.","family":"Limdi","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"},{"name":"Northern Care Alliance NHS Foundation Trust  Greater Manchester 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