{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:49:49Z","timestamp":1776084589613,"version":"3.50.1"},"reference-count":217,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Around 10% of Americans meet the Rome IV criteria for functional dyspepsia (FD), with a significantly higher rate in women. FD also has a higher prevalence in women below the age of 50, suggesting that women who are affected are likely to be of reproductive age. Unfortunately, there is a lack of research or evidence\u2010based guidelines on managing FD in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Methods<\/jats:title><jats:p>To address this issue, we aimed to perform a systematic review of the interactions between FD and pregnancy and managing pre\u2010existing FD in the peripartum and post\u2010partum phases using current lifestyle, pharmacological, non\u2010pharmacological and alternative medicine interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Due to the lack of Rome IV FD\u2010specific data in pregnancy, we instead performed a narrative review on how existing FD interventions could be extrapolated to the pregnant population. Where possible we use the highest level of available evidence or official guidelines to answer these questions, which often involves synthesising treatment and safety evidence of these interventions in other diseases during pregnancy. Finally, we highlight current substantial knowledge gaps requiring further research for the safe management of a pregnant patient with pre\u2010existing FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, despite the paucity of knowledge of treating FD during pregnancy, providers can mitigate this uncertainty by planning ahead with the patient. Patients should ideally minimise treatment until after breastfeeding. However, interdisciplinary resources are available to ensure that minimal\u2010risk interventions are maximised, while interventions with more risks, if necessary, are justifiable by both the patient and the care team. Future investigations should continue to elicit the mechanistic relationship between FD and pregnancy while cautiously expanding prospective research on promising and safe therapies in pregnant patients with pre\u2010existing FD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17534","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T11:55:03Z","timestamp":1683028503000},"page":"1375-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Review article: Functional dyspepsia and pregnancy\u2014Effects and management in a special population"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-7607","authenticated-orcid":false,"given":"Benjamin D.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine Case Western Reserve University\/Metrohealth Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Starkey","sequence":"additional","affiliation":[{"name":"Department of Medicine Case Western Reserve University\/Metrohealth Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleena","family":"Virani","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"Pichette","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Case Western Reserve University\/Metrohealth Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Fass","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University\/MetroHealth Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengqing","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Case Western Reserve University\/MetroHealth Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485408"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001362\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.81"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102014\u2010307843"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(18)30003\u20107"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004366"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004812"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30469\u20104"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2001.0239"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0889\u20108545(05)70204\u20107"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.03.009"},{"issue":"7","key":"e_1_2_11_16_1","first-page":"569","article-title":"Heartburn and regurgitation in pregnancy. Efficacy and innocuousness of treatment with Gaviscon suspension. [Pyrosis et r\u00e9gurgitations au cours de la grossesse. Efficacit\u00e9 et innocuit\u00e9 d'un Traitement Par Gaviscon Suspension]","volume":"83","author":"Uzan M","year":"1988","journal-title":"Revue Francaise de Gynecologie et D'obstetrique"},{"key":"e_1_2_11_17_1","first-page":"48","article-title":"Comparative study of Algicon suspension and magnesium trisilicate mixture in the treatment of reflux dyspepsia of pregnancy","volume":"66","author":"Lang GD","year":"1989","journal-title":"Br J Clin Pract Suppl"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12377"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.014"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001124"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357854"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12419"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.219"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203718666170612104719"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016844"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350170056"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13546"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/joe\u201012\u20100421"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12742"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.008615"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1024\/0040\u20105930.56.10.597"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.09.043"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.154"},{"key":"e_1_2_11_34_1","unstructured":"Administration FaD.Food safety for pregnant women and their unborn babies;2023. Available from:https:\/\/www.fda.gov\/food\/people\u2010risk\u2010foodborne\u2010illness\/food\u2010safety\u2010pregnant\u2010women\u2010and\u2010their\u2010unborn\u2010babies"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00023"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102017\u2010313750"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15694"},{"key":"e_1_2_11_38_1","unstructured":"IacovouDM.The low FODMAP diet during pregnancy.2016Available from:https:\/\/www.monashfodmap.com\/blog\/the\u2010low\u2010fodmap\u2010diet\u2010during\u2010pregnancy\/"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010008\u20100698\u20108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i5.456"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13697"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.159285"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102057"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.09.007"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000161"},{"key":"e_1_2_11_46_1","first-page":"1344","volume-title":"Dietary reference intakes: the essential guide to nutrient requirements","author":"Io M","year":"2006"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23553"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001029"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/ogx.0000000000000329"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.06.004"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00226\u20100"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i3.654"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.049"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2005.03.001"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i27.3242"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"issue":"03","key":"e_1_2_11_57_1","first-page":"1","article-title":"Diagnosis and management of Q fever\u2014United States, 2013: recommendations from CDC and the Q Fever Working Group","volume":"62","author":"Anderson A","year":"2013","journal-title":"MMWR Recommendations Rep"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.377"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447\u20100756.2010.01246.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.171"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/s1064744996000646"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1983.11.2.114"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.1981.tb16553.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00119\u201008"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237958"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2002.130611"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12562"},{"key":"e_1_2_11_68_1","unstructured":"Point of care medical application: Epocrates. Athenahealth.2022Available from:https:\/\/www.epocrates.com\/"},{"issue":"233","key":"e_1_2_11_69_1","first-page":"72063","article-title":"Content and format of labeling for human prescription drug and biological products; requirements for pregnancy and lactation labeling. Final rule","volume":"79","author":"Food and Drug Administration, HHS","year":"2014","journal-title":"Fed Regist"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7004a1"},{"key":"e_1_2_11_71_1","unstructured":"Organization WH.Breastfeeding and maternal medication: recommendations for drugs in the Eleventh WHO Model List of Essential Drugs.2002."},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2012.9977"},{"issue":"03","key":"e_1_2_11_73_1","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR Recommendations Rep"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.supplement_1.s3"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002708"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.02.005"},{"issue":"13","key":"e_1_2_11_77_1","first-page":"613","article-title":"Thrombocytopenic purpura in an infant after administration of acetylsalicylic acid to the wet\u2010nurse. [Porpora trombocitopenica in lattante dopo somministrazione di acido acetilsalicilico alla nutrice]","volume":"19","author":"Terragna A","year":"1967","journal-title":"Minerva Pediatrica"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128072\u2010200002030\u201000006"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105085(99)70171\u2010x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011194.pub3"},{"issue":"11","key":"e_1_2_11_81_1","first-page":"763","article-title":"Treatment of gastroesophageal reflux disease during pregnancy","volume":"8","author":"Gerson LB","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/1998\/167174"},{"key":"e_1_2_11_83_1","unstructured":"HalesMeds.Springer Publishing.2023[cited 2023 February 18]."},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15914"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1015863018105"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.122"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002689"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20102115(00)00388\u20102"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15611"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u20102803.201700000\u201042"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009350483"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15610"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2018.0124"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.05.010"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.06.014"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318199f17e"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.051"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i42.6127"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010310721"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326\u20105377.1991.tb112889.x"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1462"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.4.312"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.040"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312828"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210\u2010200620030\u201000002"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.25.3.411.61597"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ba0632"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000291559.02462.7f"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261\u2010015\u20100360\u20100"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5370"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010021\u201001077\u20109"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.013"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.96"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1177\/0890334416680176"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010301454"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002621"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002833"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(16)37926\u20101"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.01.010"},{"issue":"2","key":"e_1_2_11_120_1","first-page":"57","article-title":"Transfer of antibiotics into maternal milk","volume":"5","author":"Matsuda S","year":"1984","journal-title":"Biol Res Pregnancy Perinatol"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2008.0135"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1908"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278343"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807154"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200007133430208"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.18433\/j3ds3r"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.06.036"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.427"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737\u2010022\u201001250\u20108"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.15.supplementi_31"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16072"},{"key":"e_1_2_11_132_1","unstructured":"Sulpiride 200mg Tablets Product Monograph. Wockhardt UK Ltd. [cited 2022 December 17]. Available from:https:\/\/www.medicines.org.uk\/emc\/product\/2430\/smpc"},{"key":"e_1_2_11_133_1","volume-title":"Sulpiride. Drugs and lactation database (LactMed)","year":"2006"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479000"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020341"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010017\u20101629\u20105"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274467"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114519003374"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009951.pub3"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13945"},{"key":"e_1_2_11_141_1","unstructured":"Rifaximin (XIFAXAN) for Irritable Bowel Syndrome with Diarrhea National Drug Monograph.2022Available from:https:\/\/www.pbm.va.gov\/PBM\/clinicalguidance\/drugmonographs\/Rifaximin_XIFAXAN_IBS_D_Monograph.pdf"},{"key":"e_1_2_11_142_1","first-page":"e1965","article-title":"Topical mastic oil for treatment of functional dyspepsia: a randomized","volume":"10","author":"Sattarzadeh MB","year":"2021","journal-title":"Triple\u2010Blind Controlled Trial"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14044"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010007\u20102067\u20103"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101300528"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12102"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103940(01)02527\u20107"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000021"},{"issue":"7","key":"e_1_2_11_149_1","first-page":"1027","article-title":"Peppermint oil","volume":"75","author":"Kligler B","year":"2007","journal-title":"Am Fam Phys"},{"issue":"2","key":"e_1_2_11_150_1","first-page":"36","article-title":"Exposure to specific herbal products during pregnancy and the risk of low birth weight","volume":"18","author":"Moussally K","year":"2012","journal-title":"Altern Ther Health Med"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010313425"},{"key":"e_1_2_11_152_1","unstructured":"Drugs and Lactation Database (Lactmed). [cited 2022 December 8]. Available from:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK501791\/"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2020.1856996"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/915087"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887116666210612034911"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i1.105"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002456"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2012.08.001"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1177\/2156587216654601"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2010.10.003"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12348"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.442"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655\u2010021\u20103487\u20107"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg401"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.02.030"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2003.01767.x"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0944\u20107113(11)80027\u20109"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.01.004"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01142.x"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201005380\u2010y"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2022.102873"},{"key":"e_1_2_11_172_1","unstructured":"Iberogast Product Page. Bayer. Available from:https:\/\/www.iberogast.com.au\/products\/iberogast"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2040"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.08.005"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14467"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der335"},{"key":"e_1_2_11_177_1","unstructured":"Opinion of the French Agency for Food Environmental and Occupational Health & Safety on the Risks Associated with the Presence in Food Supplements of P\u2010synephrine or Ingredients Obtained from Citrus Spp. Fruits Containing This Substance. ANSES. [cited 2022 December 8]. Available from:https:\/\/www.anses.fr\/en\/system\/files\/NUT2012sa0200EN.pdf"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26246"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.87a.19054"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2020.05.001"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010041217\u2010011106"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)32115\u20102"},{"key":"e_1_2_11_183_1","unstructured":"PalliA.Psychoeducation: the way to make patients manage their illness and fill their future with life short communication;2018."},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12410"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105868\u20109\u201019"},{"key":"e_1_2_11_186_1","unstructured":"DISORDER WGOMD.Practice guideline for the treatment of patients with major depressive disorder. Third Edition ed. American Psychiatric Association;2010:152. Accessed April 12th 2023."},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2007.03277.x"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.7326\/m19\u20102880"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13316"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102982.2008.01164.x"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001882"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.781215"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1136\/aim.2009.000497"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2019.1391"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1097\/ogx.0000000000000655"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010022\u201006201\u2010w"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed\u20102013\u2010010480"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006946.pub4"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1177\/08903344221078802"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1097\/nmc.0000000000000866"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14518"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(17)30253\u20104"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150052"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000559"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100038\u2010z"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010020\u201001063\u20101"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010015\u20100708\u20102"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010021\u201006220\u20106"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144048"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1113\/ep090187"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68238-9"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192\u2010020\u201004594\u2010w"},{"issue":"4","key":"e_1_2_11_213_1","first-page":"479","article-title":"The influence of acupuncture stimulation during pregnancy: the induction and inhibition of labor","volume":"50","author":"Tsuei JJ","year":"1977","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12345"},{"key":"e_1_2_11_215_1","unstructured":"DavidC MontenegroM SpiegelB LacyBE.Virtual Reality Improves Symptoms Of Functional Dyspepsia: Results of a Randomized Controlled Double\u2010Blind Pilot Study. presented at: ACG 2022 Annual Scientific Meeting.2022Charlotte NC. Available from:https:\/\/www.eventscribe.net\/2022\/ACG2022\/fsPopup.asp?PresentationID=1140526&mode=presinfo"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.13413"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010021\u201003725\u20105"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101708851"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T02:11:26Z","timestamp":1702433486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":217,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/apt.17534"],"URL":"https:\/\/doi.org\/10.1111\/apt.17534","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"2022-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}