{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:34:03Z","timestamp":1789569243976,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>We conducted a systematic review to assess medical therapy for the treatment and prevention of pouchitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomised controlled trials (RCTs) of medical therapy in adults with or without pouchitis were searched to March 2022. Primary outcomes included clinical remission\/response, maintenance of remission and prevention of pouchitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty RCTs (<jats:italic>N<\/jats:italic>\u2009=\u2009830) were included. Acute pouchitis: One study compared ciprofloxacin with metronidazole. At 2\u2009weeks, 100% (7\/7) of ciprofloxacin participants achieved remission, compared with 67% (6\/9) of metronidazole participants (RR: 1.44, 95% CI: 0.88\u20132.35, very low certainty evidence). One study compared budesonide enemas with oral metronidazole. Fifty percent (6\/12) of budesonide participants achieved remission compared with 43% (6\/14) of metronidazole participants (RR: 1.17, 95% CI: 0.51\u20132.67, low certainty evidence). Chronic pouchitis: Two studies (<jats:italic>n<\/jats:italic>\u2009=\u200976) assessed De Simone Formulation. Eighty\u2010five percent (34\/40) of De Simone Formulation participants maintained remission at 9\u201312\u2009months compared with 3% (1\/36) placebo participants (RR: 18.50, 95% CI: 3.86\u201388.56, moderate certainty evidence). One study assessed vedolizumab. Thirty\u2010one percent (16\/51) of vedolizumab participants achieved clinical remission at 14\u2009weeks compared with 10% (5\/51) of placebo participants (RR: 3.20, 95% CI: 1.27\u20138.08, moderate certainty evidence). Prophylaxis: Two studies assessed De Simone Formulation. Ninety percent (18\/20) of De Simone Formulation participants did not develop pouchitis compared with 60% (12\/20) of placebo participants (RR: 1.50, 95% CI: 1.02\u20132.21, moderate certainty evidence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Apart from vedolizumab and the De Simone formulation, the effects of other medical interventions for pouchitis are uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17568","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:12:01Z","timestamp":1685351521000},"page":"268-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Systematic review and meta\u2010analysis of randomised controlled trials: Medical therapies for the treatment and prevention of pouchitis"],"prefix":"10.1111","volume":"58","author":[{"given":"Lotus","family":"Alphonsus","sequence":"first","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theshani A.","family":"De\u00a0Silva","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-9948","authenticated-orcid":false,"given":"Christopher","family":"Ma","sequence":"additional","affiliation":[{"name":"Alimentiv, Inc.  London Ontario Canada"},{"name":"Division of Gastroenterology &amp; Hepatology, Department of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences Cumming School of Medicine, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Alimentiv, Inc.  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-8014","authenticated-orcid":false,"given":"Jurij","family":"Hanzel","sequence":"additional","affiliation":[{"name":"Alimentiv, Inc.  London Ontario Canada"},{"name":"Department of Gastroenterology, Faculty of Medicine University Medical Center Ljubljana, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Beaton","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry, Western University  London Ontario Canada"},{"name":"Department of Medicine, Division of Gastroenterology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Bessissow","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine McGill University Health Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-950X","authenticated-orcid":false,"given":"Maia","family":"Kayal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Sedano","sequence":"additional","affiliation":[{"name":"Alimentiv, Inc.  London Ontario Canada"},{"name":"Department of Medicine, Division of Gastroenterology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-7269","authenticated-orcid":false,"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-0033","authenticated-orcid":false,"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Alimentiv, Inc.  London Ontario Canada"},{"name":"Department of Medicine, Division of Gastroenterology Western University  London Ontario Canada"},{"name":"Department of Epidemiology and Biostatistics Western University  London Ontario Canada"},{"name":"Lawson Health Research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab124"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16328"},{"key":"e_1_2_10_4_1","volume-title":"Entyvio\u2010H\u2010C\u20102782\u2010II\u20100061: EPAR \u2013 Assessment report \u2013 Variation","author":"European Medicines Agency","year":"2022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21039"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05697-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac190.0008"},{"issue":"8","key":"e_1_2_10_8_1","first-page":"329","article-title":"Mucosal healing with vedolizumab in inflammatory bowel disease: evidence from Earnest, a randomized, double\u2010blind, placebo\u2010controlled trial in chronic Pouchitis","volume":"10","author":"Jairath V","year":"2022","journal-title":"United European Gastroenterol J"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"issue":"4","key":"e_1_2_10_13_1","article-title":"Bifidobacterium longum BB\u2010536 and prevention of acute pouchitis","volume":"126","author":"Brown SJMJ","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_10_14_1","unstructured":"NCT02790138. A Randomized Double\u2010Blind Placebo\u2010Controlled Phase 4 Study to Evaluate the Efficacy and Safety of Entyvio (Vedolizumab IV) in the Treatment of Chronic Pouchitis (EARNEST).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02790138. Accessed 1 Aug 2022."},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"S365","DOI":"10.14309\/01.ajg.0000776672.02201.55","article-title":"Alicaforsen enema in chronic pouchitis: results of a phase 3 randomized, double\u2010blind, placebo\u2010controlled trial","volume":"116","author":"Feagan BLJ","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9370"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00171-9"},{"issue":"5","key":"e_1_2_10_18_1","first-page":"S69","article-title":"Early institution of tinidazole may prevent pouchitis following ileal pouch\u2010anal anastomosis (IPAA) surgery in ulcerative colitis (UC) patients","volume":"138","author":"Ha CYBJ","year":"2010","journal-title":"Gastroenterology"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497042"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20187"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520152584815"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1569718"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01465.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.108"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20369"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01139.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200111000-00004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00665.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00253.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02838.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-015-1261-9"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"51","article-title":"Alicaforsen: an emerging therapeutic agent for ulcerative colitis and refractory pouchitis","volume":"7","author":"Hosten TA","year":"2014","journal-title":"Gastroenterology Res"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.17568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:01:03Z","timestamp":1692334863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.17568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/apt.17568"],"URL":"https:\/\/doi.org\/10.1111\/apt.17568","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]},"assertion":[{"value":"2023-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}