{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:51:36Z","timestamp":1790016696929,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disturbance of skeletal muscle mass has clinically important implications in patients with inflammatory bowel disease (IBD), but accurate quantification requires radiation\u2010intense techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to compare point\u2010of\u2010care muscle assessments and their change with therapy with those using reference\u2010standard whole\u2010body dual energy X\u2010ray absorptiometry (DXA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with IBD and healthy controls underwent prospective assessment of muscularity by ultrasound of the dominant arm and both thighs, bioelectrical impedance analysis (BIA), anthropometric measurements, and DXA. Patients with active IBD were assessed again \u226513\u2009weeks after initiating biologic induction therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 54 patients with IBD and 30 controls, all muscle assessments correlated significantly with DXA\u2010derived skeletal muscle index (SMI). In IBD, ultrasound of the arm and legs had the best agreement with DXA\u2010derived SMI (mean difference 0\u2009kg\/m<jats:sup>2<\/jats:sup>, 95% limits of agreement \u22121.3 to 1.3), while BIA overestimated DXA\u2010derived SMI by 1.07 (\u22120.16 to +2.30)\u2009kg\/m<jats:sup>2<\/jats:sup>. In 17 patients who underwent biologic therapy, the percentage change in DXA\u2010derived SMI correlated significantly with the percentage change in all other muscle assessment techniques. Responders (<jats:italic>n<\/jats:italic>\u2009=\u20099) increased SMI from baseline to follow\u2010up when derived from DXA (mean 7.8\u20138.5\u2009kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), ultrasound of the arm and legs (300\u2013343\u2009cm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.021) and BIA (9.2\u20139.6\u2009kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound of the arm and legs out\u2010performed other point\u2010of\u2010care methods in its accuracy of measuring muscle mass. All methods, except mid\u2010arm circumference, were responsive to therapy\u2010induced change. Ultrasound is the preferred non\u2010invasive test for measuring muscle mass in patients with IBD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17607","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T08:35:11Z","timestamp":1686558911000},"page":"309-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Accuracy of ultrasound, bioelectrical impedance analysis and anthropometry as point\u2010of\u2010care measurements of skeletal muscle mass in patients with inflammatory bowel disease"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-3325","authenticated-orcid":false,"given":"Anke L.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Gastroenterology Department Monash Health  Victoria Melbourne Australia"},{"name":"Department of Gastroenterology Central Clinical School, Monash University and Alfred Health  Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-1638","authenticated-orcid":false,"given":"Megan","family":"Burns","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Monash Health  Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-2083","authenticated-orcid":false,"given":"Madhuni","family":"Herath","sequence":"additional","affiliation":[{"name":"Endocrinology Department Monash Health  Victoria Melbourne Australia"},{"name":"Department of Medicine, School of Clinical Sciences Monash University  Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-3023","authenticated-orcid":false,"given":"Kate","family":"Lambell","sequence":"additional","affiliation":[{"name":"Nutrition Department Alfred Health  Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-6279","authenticated-orcid":false,"given":"Darcy","family":"Holt","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Monash Health  Victoria Melbourne Australia"},{"name":"Department of Medicine, School of Clinical Sciences Monash University  Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-8135","authenticated-orcid":false,"given":"Jessica","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Central Clinical School, Monash University and Alfred Health  Victoria Melbourne Australia"},{"name":"Nutrition Department Alfred Health  Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-4376","authenticated-orcid":false,"given":"Frances","family":"Milat","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Sciences Monash University  Victoria Melbourne Australia"},{"name":"Centre for Endocrinology &amp; 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