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The primary outcomes were abstinence, hepatic decompensation and mortality. We included randomised and non\u2010randomised studies. Risk of bias was assessed using validated tools. Where possible, meta\u2010analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three studies met the inclusion criteria including six randomised trials and 17 non\u2010randomised studies of interventions. These included 104,298 patients with a mean\/median age range from 44 to 65, of whom 75% were male. Interventions included psychological therapy, pharmacological therapies, specialist clinics, patient education and low alcohol drinks. Baclofen was the only intervention to demonstrate a statistically significant impact on the primary outcomes in a randomised trial (abstinence OR: 6.3, 95% CI: 2.4\u201316.1). Three non\u2010randomised studies reported reductions in episodes of hepatic decompensation that were significant in multivariate models. This was in response to psychological therapy, use of any pharmacotherapy, and use of any treatment. A meta\u2010analysis of non\u2010randomised studies that examined the impact of psychological therapies revealed statistically non\u2010significant improvements in abstinence (4 studies, OR: 1.87, 95% CI: 0.38\u20139.23) and mortality (4 studies, OR: 0.47, 95% CI: 0.12\u20131.77).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baclofen is the only intervention with randomised trial evidence for significant benefit in patients with cirrhosis. Non\u2010randomised studies also point to non\u2010pharmaceutical interventions possibly improving clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17665","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:40:52Z","timestamp":1692654052000},"page":"763-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Systematic review: Interventions for alcohol use disorder in patients with cirrhosis or alcohol\u2010associated hepatitis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-8345","authenticated-orcid":false,"given":"Christopher","family":"Oldroyd","sequence":"first","affiliation":[{"name":"Cambridge NIHR Biomedical Research Centre  Cambridge UK"},{"name":"Cambridge Liver Unit Cambridge University Hospitals NHS Foundation Trust  Cambridge 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