{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:50:59Z","timestamp":1778802659507,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) represents a significant health threat worldwide. The growing trend towards an aging population, along with an alarming rise in obesity and diabetes, may have significant implications for the burden of NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the impact of NAFLD on the elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilised data from the Global Burden of Disease study between 2010 and 2019 to conduct a comprehensive analysis of the prevalence, mortality, and disability\u2010adjusted life years (DALYs) associated with NAFLD in the elderly (65\u201389\u2009years), stratified by region, nation, sociodemographic Index and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Globally, there were an estimated 228 million cases, 87,230 deaths and 1.46 million DALYs attributed to NAFLD in the elderly. Geographically, the Western Pacific region had the highest burden of NAFLD in the elderly. From 2010 to 2019, there was an increasing prevalence rate in all areas, with the most pronounced change observed in the Western Pacific region (annual percentage change (APC) +0.95%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Over the study period, there was a more rapid increase in NAFLD prevalence in men (APC +0.74%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) than in women (APC +0.63%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In most regions, death and DALYs rates have declined, with the exception of the Americas, where there was a slight increase (APC +0.25%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002 and 0.38%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over the past decade, the burden of NAFLD in the elderly has been increasing, necessitating immediate and inclusive measures to tackle the rising burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17714","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:05:39Z","timestamp":1694430339000},"page":"1062-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The silent burden of non\u2010alcoholic fatty liver disease in the elderly: A global burden of disease analysis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-165X","authenticated-orcid":false,"given":"Pojsakorn","family":"Danpanichkul","sequence":"first","affiliation":[{"name":"Immunology Unit, Department of Microbiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-1569","authenticated-orcid":false,"given":"Cheng Han","family":"Ng","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-4743","authenticated-orcid":false,"given":"Mark D.","family":"Muthiah","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine 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Yu","family":"Wong","sequence":"additional","affiliation":[{"name":"Nottingham City Hospital Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-176X","authenticated-orcid":false,"given":"Nicholas","family":"Syn","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubasa","family":"Tsusumi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Shadab","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boston VA Healthcare System, and Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"},{"name":"Faculty of Medicine Harvard University  Boston Massachusetts 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