{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:07:48Z","timestamp":1794478068174,"version":"4.9.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010erosive reflux disease (NERD) symptoms are often episodic, making on\u2010demand treatment an attractive treatment approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We compared the efficacy and safety of on\u2010demand vonoprazan versus placebo in patients with NERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with NERD, defined as heartburn for \u22656\u2009months and for \u22654\/7 consecutive days with normal endoscopy, received once\u2010daily vonoprazan 20\u2009mg during a 4\u2010week run\u2010in period. Patients without heartburn during the last 7\u2009days and with \u226580% study drug and diary compliance were randomised 1:1:1:1 to vonoprazan 10, 20, 40\u2009mg or placebo on\u2010demand for 6\u2009weeks. The primary endpoint was the percentage of evaluable heartburn episodes completely relieved within 3\u2009h of on\u2010demand dosing and sustained for 24\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 458 patients in the run\u2010in period, 207 entered the on\u2010demand period. In the vonoprazan 10 mg group, 56.0% (201\/359) of evaluable heartburn episodes met the criteria for complete and sustained relief; 60.6% (198\/327) in the 20 mg group; and 70.0% (226\/323) in the 40 mg group, compared with 27.3% (101\/370) in the placebo group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 versus placebo for each vonoprazan group). By 1\u2009h post\u2010dose, vonoprazan was associated with complete relief of significantly more heartburn episodes compared with placebo. No serious treatment\u2010emergent adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>On\u2010demand vonoprazan may be a potential alternative to continued daily acid suppression therapy for the relief of episodic heartburn in patients with NERD.<\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>: NCT04799158.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.17728","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:45:06Z","timestamp":1695725106000},"page":"1016-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Randomised clinical trial: Efficacy and safety of <scp>on\u2010demand<\/scp> vonoprazan versus placebo for non\u2010erosive reflux disease"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-3052","authenticated-orcid":false,"given":"Ronnie","family":"Fass","sequence":"first","affiliation":[{"name":"The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical System Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-8727","authenticated-orcid":false,"given":"Prateek","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kansas City VA Medical Center  Kansas City Missouri USA"},{"name":"Department of Gastroenterology and Hepatology University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Yadlapati","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Center for Esophageal Diseases University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Hunt","sequence":"additional","affiliation":[{"name":"Phathom Pharmaceuticals Research and Development  Buffalo Grove Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Harris","sequence":"additional","affiliation":[{"name":"Phathom Pharmaceuticals Research and Development  Buffalo Grove Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neila","family":"Smith","sequence":"additional","affiliation":[{"name":"Phathom Pharmaceuticals Research and Development  Buffalo Grove Illinois 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